天津医药

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周围型肺癌超声造影表现与微血管密度的相关性研究

秦玉华   

  1. 河北北方学院
  • 收稿日期:2013-01-16 修回日期:2013-02-28 出版日期:2013-10-15 发布日期:2013-10-15
  • 通讯作者: 秦玉华

　　　Study on correlation between contrast-enhanced sonography parameters and microvessel density of pleural-based pulmonary carcinoma

  • Received:2013-01-16 Revised:2013-02-28 Published:2013-10-15 Online:2013-10-15

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摘要：

 【摘要】  目的  探讨周围型肺癌超声造影表现与肿瘤微血管密度（MVD）的关系。 方法 40例经超声引导下穿刺活检确诊的周围型肺癌（腺癌22例，鳞癌18例）,穿刺前行超声造影检查，穿刺后行常规病理检查及CD34免疫组织化学染色并计算MVD。用时间强度曲线分析腺癌和鳞癌的峰值强度及增强强度指数，计算强度参数与MVD的相关性。  结果  腺癌的MVD（28.5±6.2）、造影峰值强度（69.5±13.6）及强度指数（5.1±1.6）均高于鳞癌（分别为23.8±8.4、53.4±15.2及4.0±1.3，均P＜0.05）。肺腺癌超声造影峰值强度及强度指数与其MVD呈正相关（r分别为0.654及0.776）；肺鳞癌峰值强度及强度指数与其MVD呈正相关（r分别为0.811及0.878）。  结论   超声造影可以动态评价周

关键词: 肺肿瘤, 癌, 超声造影, 微血管密度

Abstract: 　　　Abstract: objective to investigate the relationship between contrast-enhanced sonographic characteristics and tumor microvessel density (MVD) in pleural-based lung cancer. Methods 40 patients with biopsy-proven pleural-based lung cancer (22 patients with adenocarcinoma and 18 patients with squamous cell carcinoma) performed contrast-enhanced sonography prior to biopsy procedure. MVD of the biopsy specimens were assessed by histochemical staining using a mouse antihuman CD34 monoclonal antibody. Peak enhancement and enhancement index derived from time intensity curve were correlated with MVD. Results Lung adenocarcimoma showed statistically higher value than squamous cell carcinoma in respect to PE , EID, and MVD（P＜0.01）. A linear positive correlation was reveal between enhancement parameters (PE, EID) and MVD for both adenocarcimoma and squamous cell carcinoma（P＜0.01）. Conclusion Peak enhancement and enhancement index of pleural-based lung cancer on contrast-enhanced sonography were correlated with tumor’s MVD. This indicates that contrast-enhanced sonography can be used to evaluate angiogenesis of pleural-based lung cancer.