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异维A酸治疗重度痤疮的疗效观察

唐志凌   

  1. 蓟县人民医院
  • 收稿日期:2012-03-12 修回日期:2012-09-27 出版日期:2013-02-15 发布日期:2013-02-15
  • 通讯作者: 唐志凌

Efficacy of Isotretinoin in the treatment of severe acne

  • Received:2012-03-12 Revised:2012-09-27 Published:2013-02-15 Online:2013-02-15

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摘要： 唐志凌 天津市蓟县人民医院皮肤科（301900） 【摘要】 目的 观察异维A酸治疗重度痤疮的疗效。方法 将受试者随机分为两组，试验组中体重≥50kg者，隔日口服异维A酸10mg，每日3次；体重<50 kg者，隔日口服异维A酸10mg，每日2次。对照组:盐酸米诺环素50mg每日2次。两组患者疗程均为8周。治疗第1、2、4、6、8周及停药后2、4、6周，分别对两组患者有效率进行评分比较。结果 在治疗第2、4、6、8周，试验组与对照组比较，有效率均差异显著。在停药后2、4、6周，试验组和与对照组比较，有效率仍有显著差异。结论 异维A酸治疗重度痤疮的疗效优于米诺环素。

关键词: 痤疮, 重症, 异维A酸, 疗效

Abstract: Tang zhiling,Dermatology department of Tianjin Jixian people's Hospital （301900） [Abstract] Objective To observe the efficacy of Isotretinoin in the treatment of severe acne . Methods The persons being tested were randomly divided into two groups , body weight ≥ 50kg in the test group, every other day took orally 10mg Isotretinoin , 3 times a day ; body weight <50 kg , every other day took orally 10mg Isotretinoin 2 times a day . Control group : 50mg minocycline hydrochloride twice daily . Treatment time of the both two groups of patients lasted for 8 weeks .At the 2th,4th and 6th week in the treatment and the 1th, 2th, 4th, 6th and the 8th week after the treatment, we compared efficiency scores respectively between the two groups of patients . Results At the 2th,4th,6th and the 8th week in the treatment , we compared the test group and the control group , the effective rate was significantly different . At the 4th and 6th week after the treatment,we compared the test group with the control group,the effective rate was still significantly different.Conclusions Isotretinoin in the treatment of severe acne was more effective than minocycline .

Key words: acne, severe, sotretinoin, efficacy