天津医药 ›› 2025, Vol. 53 ›› Issue (3): 331-336.doi: 10.11958/20242422
• 综述 • 上一篇
范慧娟1,2(), 刘涛涛2, 李楠1,2, 夏时海2,△(
)
收稿日期:
2024-12-30
修回日期:
2025-02-17
出版日期:
2025-03-15
发布日期:
2025-03-31
通讯作者:
E-mail:作者简介:
范慧娟(1999),女,硕士在读,主要从事消化系统疾病方面研究。E-mail:基金资助:
FAN Huijuan1,2(), LIU Taotao2, LI Nan1,2, XIA Shihai2,△(
)
Received:
2024-12-30
Revised:
2025-02-17
Published:
2025-03-15
Online:
2025-03-31
Contact:
E-mail:范慧娟, 刘涛涛, 李楠, 夏时海. 间充质干细胞治疗急性胰腺炎的机制及研究进展[J]. 天津医药, 2025, 53(3): 331-336.
FAN Huijuan, LIU Taotao, LI Nan, XIA Shihai. Mechanism and research progress of mesenchymal stem cell therapy for acute pancreatitis[J]. Tianjin Medical Journal, 2025, 53(3): 331-336.
摘要:
急性胰腺炎(AP)是一种自身消化性疾病,且可伴随全身炎症反应及多器官功能衰竭,间充质干细胞(MSCs)已用于AP治疗中并展现出良好的应用潜力,其可通过归巢至损伤部位、抗炎及免疫调节、抗氧化应激、抗凋亡及抗自噬等机制,有效减轻胰腺炎症并促进组织修复。此外,MSCs还可改善AP引起的肺、肠及心脏等多器官损伤。MSCs治疗AP的研究仍停留在动物实验阶段,临床研究较少。该文综述了MSCs治疗AP的相关机制及研究进展,以为其基础研究及临床应用提供参考。
中图分类号:
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