关键词: 组织蛋白酶类, 酶抑制剂, 骨质疏松, 综述, 组织蛋白酶 K, Odanacatib

Abstract:

[Abstract] The prevalence of osteoporosis has increased during recent years. The activation in the function of osteo?
clast is the main reason of osteoporosis. Cathepsin is expressed by osteoclast and involved in the degradation of collagen of bone, and causes osteoporosis. Cathepsin K is a kind of most important enzyme in the family of cathepsin. Odanacatib（ODN）is the inhibitor of cathepsin K, and it may be used to anti-osteoporosis thought inhibiting the degradation of bone collagen. It was found that the cortical thickness and bone minerals of cancellous increased after taking ODN in the studies, and then the density and the strength of bone increased. This study reviewed the pharmacological profile of ODN and the progresses of animal study and clinical trials about ODN.

Key words: cathepsins, enzyme inhibitors, osteoporosis, review, cathepsin K, odanacatib