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连续使用卷曲霉素6个月治疗耐多药肺结核不良反应分析

潘洪秋1,许卫国2,陈永忠1,季小平1,杨珏1,严金二1   

  1. 1. 镇江市第三人民医院
    2. 江苏省疾病控制中心
  • 收稿日期:2011-01-21 修回日期:2011-06-01 出版日期:2011-11-15 发布日期:2011-11-15
  • 通讯作者: 潘洪秋

Side effect of capreomycin regimen on multi-drug resistant tuberculosis continuity for six monthes

  • Received:2011-01-21 Revised:2011-06-01 Published:2011-11-15 Online:2011-11-15

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摘要： 【摘要】目的：了解卷曲霉素(CPM)的不良反应和连续使用6个月的安全性。方法：分析20例含连续使用6个月卷曲霉素方案治疗的耐多药肺结核患者发生的不良反应。结果：20例中发生与卷曲霉素有关的不良反应发生率100%。共发生6种不良反应，其频率依次为局部硬结或疼痛、低血钾、静脉炎、肾功能损害以及头晕耳鸣。发生时间多在用药2-4月，经过及时处理，所有患者都使用卷曲霉素6个月。使用卷曲霉素 6个月结束后观察12个月没有发生其它不良反应。结论： 连续使用6个月卷曲霉素引起的不良反应常见，以局部硬结、低血钾多见，经处理能继续使用至6个月。

关键词: 卷曲霉素, 不良反应, 耐多药结核病

Abstract: 【Abstract】 Objective: To observe the side effect of capreomycin(CPM) and the safety of using CPM continuty for six monthes.Methods: Investigate the side effect of 20 multi-drug resistant tuberculosis patients who had used CPM continuity for six monthes.Results:All of the 20 patients had side effects,the rat was 100%. Frequency of the side effects was seleroma,hypokalemia,renal injury,Ⅷ cranial nerve's injury, Phlebitis.The side effects frequently appeared after 2-4 months of treatment. After rapid treatment and active observation ,all of them had the treatment for six monthes,and none of them had any side effects on the next six monthes.Conclusion:The side effects appeared commonly of the patients who had used CPM continuity for six monthes,and the hypokalemia was more serious.But capreomycin is a safe anti- tuberculosis drug for multi-drug resistant tuberculosis(MDR-TB).

Key words: Capreomycin(CPM), Side effect, Multi-drug resistant tuberculosis(MDR-TB)