关键词: 布地奈德, 地塞米松, 儿童, 住院, 插管法, 气管内, 治疗结果, 不良反应

Abstract: Objective To investigate the effect of budesonide atomization on tracheal extubation in children. Methods A total of 85 patients with tracheal intubation in Tianjin Children’ s Hospital from May 2013 to September 2016 were selected in this study. Patients were randomly divided into budesonide group (n=44) and dexamethasone group (n=41).The budesonide group was given 1 mg of budesonide for inhalation 30 min before extubation, and 1 mg of budesonide inhalation immediately after extubation. Then every 8 hours for 0.5- 1.0 mg budesonide inhalation for 4 days. The dexamethasone group was given dexamethasone 0.2-0.3 mg/kg intravenously 30 min before extubation, and dexamethasone 2.5-5.0 mg inhalation immediately after extubation. Then dexamethasone 2.5-5.0 mg inhalation was given every 8 hours for 4 days. The incidence of laryngeal edema (stridor, hoarseness), the time of extinction, the expression of hypoxia, reintubation rate within 24 hours and secondary infection rate after extubation were compared between the two groups.Results There were no significant differences in the mission success rate, the incidence of laryngeal edema, the time of extinction, the incidence of hypoxia and re- intubation rate between the two groups (P > 0.05). Two patients were found secondary infection after extubation in dexamethasone group. Conclusion Both budesonide and dexamethasone show curative effects on the prevention and treatment of laryngeal edema after extubation. Budesonide atomization can replace systemic corticosteroids, thus reducing the adverse reactions of glucocorticoids. We recommend the use of budesonide in treating adverse events after extubation.

Key words: budesonide, dexamethasone, child, hospitalized, intubation, intratracheal, treatment outcome, adverse reaction