天津医药

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雄激素受体基因CAG重复序列多态性与男性急性心肌梗死的关系

孟冬梅,王林,牛远杰,刘颖颖,刘黎洁   

  1. 天津医科大学第二医院
  • 收稿日期:2011-07-06 修回日期:2011-08-23 出版日期:2012-01-15 发布日期:2012-01-15
  • 通讯作者: 孟冬梅

The relationship between CAG polymorphisms of androgen receptor gene and acute myocardial infarction in men

  • Received:2011-07-06 Revised:2011-08-23 Published:2012-01-15 Online:2012-01-15

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摘要： 目的：探讨男性雄激素受体（AR）基因CAG重复序列多态性与急性心肌梗死（AMI）的关系。方法：选择112例男性急性心肌梗死患者（AMI组）和118例健康男性体检者（对照组），采用聚合酶链反应（PCR）和直接测序法测定其外周血AR基因CAG重复序列的长度。结果：AMI组和对照组CAG重复序列长度范围为12～33，平均值分别为23.09±3.52和20.33±3.65，2组间的差异有统计学意义（t=5.826,P<0.01）。与CAG重复序列长度<23相比，≥23者发生急性心肌梗死的危险性增加了4.391倍，差异有统计学意义（P<0.01）。结论：男性AR基因CAG重复序列是急性心肌梗死的危险因素。

关键词: 受体, 雄激素, 多态现象, 遗传, 心肌梗死, 急性病, 聚合酶链反应, 男(雄)性

Abstract: Objective To explore the relationship between CAG polymorph- isms of androgen receptor gene and acute myocardial infarction in men. Methods 112 acute myocardial infarction patients and 118 healthy men were selected. The length of CAG repeats in the peripheral blood AR gene was examined by PCR and direct sequencing. Results For the AMI patients and the controls, the numbers of CAG repeats ranged from 12-33,with mean values 23.09±3.520 and 20.33±3.654,respectively.There were statistically significant differences between two groups. Men with CAG repeats length of 23 or longer may be in high risk of AMI(odds ratio,4.479 ；95% CI 2.564-7.824，P<0.001),compared with men with CAG repeats length shorter than 23.Conclusions The CAG repeat polymorphism in the androgen receptor is associated with acute myocardial infarction, Men with CAG repeats length of 23 or longer may be in high risk of acute myocardial infarction .

Key words: 男(雄)性