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血清人附睾蛋白4检测对肺癌的诊断意义

于飞1,王倩2,钟殿胜2,宁超2   

  1. 1. 山东省滨州医学院附属医院
    2. 医大总医院
  • 收稿日期:2013-07-11 修回日期:2013-10-21 出版日期:2014-02-15 发布日期:2014-02-15
  • 通讯作者: 于飞

The Significance Of Detection Of Serum HE4 In The Diagnosis Of Lung Cancer

  • Received:2013-07-11 Revised:2013-10-21 Published:2014-02-15 Online:2014-02-15

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摘要： 目的：探讨血清HE4对肺癌的诊断价值，分析HE4在不同病理类型及TNM分期肺癌患者血清中的表达情况水平。方法：选取47例肺癌患者和31例健康体检者为研究对象，根据病理类型及TNM分期分组，各组血清HE4差异比较采用非参数检验；以病理诊断为金标准，绘制血清HE4、血清CEA诊断肺癌的ROC曲线。结果：肺癌组与健康组血清HE4检测值差异有统计学意义；不同病理分型及不同TNM分期的肺癌患者血清HE4检测值差异无统计学意义；血清HE4诊断肺癌的ROC曲线下面积(AUC)接近1，并且大于血清CEA诊断肺癌的ROC曲线下面积。结论：不同病理类型及TNM分期肺癌患者血清HE4水平无明显差异；血清HE4较CEA诊断肺癌的敏感度及特异度更高；检测患者血清HE4有助于肺癌诊断。

关键词: 肺癌, 人附睾蛋白4, 癌胚抗原, 诊断

Abstract: Objective: To discuss the value of serum HE4 in the diagnosis of lung cancer.To analysis the level of HE4 in different pathological types and TNM staging lung cancer patients. Methods: Forty-seven patients with lung cancer and thirty-one healthy subjects were selected to join this study.According to pathological type and TNM stage grouping, non-parametric test was used to compare the differences of the each group serum HE4.In pathological diagnosis as the gold standard, draw ROC curve of serum HE4 and serum CEA for diagnosis of lung cancer. Results: There were significant differences in serum HE4 assay values between lung cancer group and healthy group, and lung cancer group were higher than healthy group.There were no significant differences in serum HE4 assay values among different pathological types and different TNM staging of lung cancer patients.The AUC of serum HE4 was closed to 1,and greater than the AUC of serum CEA. Conclusion: There were no significant differences in the level of serum HE4 among different pathological types and different TNM staging of patients with lung cancer. Serum HE4 is a specific and sensitive index in lung cancer，even better than serum CEA. The detection of serum HE4 is useful for the diagnosis of lung cancer.

Key words: lung cancer, HE4, CEA, diagnosis