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地佐辛复合不同剂量右美托咪啶在术后静脉镇痛中的应用

于学超   

  1. 天津市港口医院麻醉科
  • 收稿日期:2012-11-20 修回日期:2013-04-14 出版日期:2013-09-15 发布日期:2013-09-15
  • 通讯作者: 于学超

Use of Dezocine combined with different dosage of Dexmedetomidine for postoperative intravenous analgesia(PIA)

  • Received:2012-11-20 Revised:2013-04-14 Published:2013-09-15 Online:2013-09-15

摘要:

【摘要】    目的   观察地佐辛混合不同剂量右美托咪啶(DEX)用于术后静脉镇痛的临床效果。   方法全麻下行经腹子宫切除术患者120例,随机分为D1、D2、D3和F组,术后静脉镇痛泵使用地佐0.6mg·kg-1+氟哌利多5mg复合不同剂量DEX(0.045、0.1、0.15mg·kg-1·h-1)或芬太尼。观察并记录患者术后1、3、6、12、24、36和48h疼痛评分,术后24h镇静评分和舒适度(BCS)评分以及发生的不良反应。  结果  各组各时点的VAS评分均小于4,D1组术后3、6、12、24h的VAS评分大于其他3组(P<0.01);各组BCS评分均大于2,D1组术后BCS评分小于D2和D3组(P<0.05);D3组术后24h的镇静评分明显高于另外3组(P<0.05);F组恶心呕吐以及锥体外系症状的发生率明显高于其他组(P<0.05);D3组心动过缓的发生率高于另外3组(P<0.05)。  结论  地佐辛混合背景剂量为0.1μg·kg-1·h-1的DEX用于术后镇痛,效果确切,不良反应较少

关键词: 右美托咪啶, 疼痛, 手术后, 镇痛, 地佐辛

Abstract: [Abstract] Objective Observe the clinical effect of dezocine combined with different dosage of dexmedetomidine for postoperative intravenous analgesia. Method Formulas of 120 cases of laparotomy which were under general anesthesia in the same induction and maintenance process and randomized into four groups were as follows: Group D1: dezocine 0.6mg/kg + Dexmedetomidine 0.045μg/(kg?h) + droperidol 5mg; Group D2: dezocine 0.6mg/kg + Dexmedetomidine 0.1μg/(kg?h) + droperidol 5mg; Group D3: dezocine 0.6mg/kg+ Dexmedetomidine 0.15μg/(kg?h) + droperidol 5mg; Group F: dezocine 0.6mg/kg+ fentanyl 10μg/kg + droperidol 5mg, all diluted into 100ml with normal saline. The background infusion rate was 2ml/h, PCIA dose 0.5ml, and lock time 15min. Outcome measures Pain score of patients at 1, 3, 6, 12, 24, 36 and 48h postoperativly, postoerative sedation scale and postoperative comfort score (BCS) at 24h and adverse reactions, e.g. nausea and vomiting, dizziness, itchy skin, respiratory depression, bradycardia, hypotension muscle rigidity and stupor. Results VAS scores in all group and at all time point were less than 4. The VAS scores of Group D1 at 3, 6, 12 and 24h postoperativly were greater than those of the other 3 groups (P<0.01). BCS scores of all groups were greater than 2. The BCS score of group D1 was less than the other 3 groups (P<0.001). The 24h postoperative sedation score of group D3 was notably higher than those of the other three groups (P<0.001). The incidence rate of nausea and vomiting and EPS (extrapyramidal symptoms) of group F was notably higher than those of the other groups (P<0.05).The incidence rate of bradyarrhythmia of group D3 was higher than those of the other three groups (P<0.05). Conclusion It is effective and has less adverse effects to use Dezocine mixed with a basal infution of 0.1μg/(kg?h) of dexmedetomidine for postoperative analgesia.