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2型糖尿病合并非酒精性脂肪性肝病血浆chemerin与炎症指标的相关性

金二荣1,王璐，2,张洁3,邸阜生4,刘聪4,洪燕青3   

  1. 1. 天津医科大学第三中心临床学院
    2. 第三中心医院代谢病科
    3. 天津市第三中心医院
    4. 天津市第三中心医院内分泌科
  • 收稿日期:2010-09-06 修回日期:2010-10-25 出版日期:2011-08-15 发布日期:2011-08-15
  • 通讯作者: 金二荣

The Study of Relationship beteen Plasma Chemerin in Type 2 Diabetes Mellitus with Nonalcoholic Fatty Liver Disease and Inflammation

  • Received:2010-09-06 Revised:2010-10-25 Published:2011-08-15 Online:2011-08-15

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摘要： 摘要 目的：揭示2型糖尿病（T2DM）合并非酒精性脂肪性肝病(NAFLD)患者血浆chemerin与炎症的关系。方法：选取T2DM同时合并NAFLD患者120例及健康志愿者60例为研究对象，T2DM合并NAFLD患者以血浆TNF-α中位数为分界点分为高TNF-α组（A组）和低TNF-α组（B组），健康志愿者为C组， 检测三组血糖、血脂、糖化血红蛋白（HbA1c）、空腹胰岛素(FINS)、内脏脂肪、高敏C反应蛋白(hs-CRP)、肿瘤坏死因子（TNF-α）、白介素-6(IL-6)、chemerin，计算稳态模型胰岛素抵抗指数（HOMA-IR），分析血浆chemerin与炎症指标的关系。结果：A组、B组血浆chemerin水平显著高于对照组（P<0.01），A组血浆chemerin水平显著高于B组（P<0.01）。T2DM合并NAFLD患者血浆chemerin水平与腰围、LDL-C、内脏脂肪、TNF-a、IL-6呈正相关；多元逐步回归分析显示内脏脂肪、TNF-α、IL-6分别是影响血浆chemerin水平的独立因素。结论：T2DM伴NAFLD血浆chemerin与炎症反应有关，可能参与糖尿病合并非酒精性脂肪性肝病的发生、发展。

关键词: 糖尿病, 2型, 非酒精性脂肪性肝病, 炎症, chemerin

Abstract: Abstract Objective:To reveal the relationship between plasma chemerin in type 2 diabetes mellitus (T2DM) with nonalcoholic fatty liver disease (NAFLD) and inflammation. Methods: To select type 2 diabetes mellitus (T2DM) with nonalcoholic fatty liver disease (NAFLD) patients 120 examples and healthy volunteers 60 examples as studied objects, according to the median of plasma TNF-α,we groupe type 2 diabetes mellitus (T2DM) with nonalcoholic fatty liver disease (NAFLD) patients into high-grade group(A group) and low-grade group (B group), healthy volunteers as C group.Detect every group blood glucose, blood lipids, HbA1c, FINS, visceral adipose tissue,hs-CRP, TNF-α,IL-6, chemerin,count HOMA-IR and analyze the relationship of plasma chemerin and inflammation. Results: The level of plasma chemerin in group A and group B were significantly increased compared with controls( P<0.01), The level of plasma chemerin in group A were significantly increased compared with group B( P<0.01).Plasma chemerin level in T2DM with NAFLD was positively correlated with waist circumference、LDL-C、visceral adipose tissue、TNF-a、IL-6. Multiple stepwise regression analysis showed that visceral adipose tissue、TNF-a、IL-6 were independent related fators in influencing the level of plasma chemerin. Conclusion:Chemerin in T2DM with NAFLD is associated with inflammation,which may contribute to the development of T2DM with NAFLD.

Key words: diabetes mellitus, type 2 , nonalcoholic fatty liver disease , inflammation, chemerin