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ICU 中心静脉置管相关血流真菌感染病原菌流行及危险因素分析*

骆雪萍   

  1. 桂林医学院附属医院
  • 收稿日期:2011-03-11 修回日期:2011-11-01 出版日期:2012-08-15 发布日期:2012-08-15
  • 通讯作者: 骆雪萍

A clinical analysis of pathogen epidemiology and risk factors of central venous catheter related bloodstream fungal infection in intensive care unit

  • Received:2011-03-11 Revised:2011-11-01 Published:2012-08-15 Online:2012-08-15

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摘要： 目的：调查重症监护病房（ICU）中心静脉置管相关血流真菌感染（CVC-RBFI）病原菌流行情况并探讨其发生的危险因素，为防治CVC-RBFI提供参考。方法：回顾性分析2006年7月至2010年12月ICU CVC-RBFI 20例患者的临床资料，与同期35例中心静脉置管相关血流细菌感染（CVC-RBBI）患者（对照组）比较相关危险因素并调查病原菌流行及耐药情况。结果：CVC-RBFI占中心静脉置管相关血流感染（CVC-RBI）的36.36%（20/55）。非白色假丝酵母菌占60%。非白色假丝酵母菌对唑类敏感率为50.00%。CVC-RBFI独立危险因素是留置多根体腔引流管（OR= 8.938，P<0.05）及外科大手术术后（OR= 11.250，P<0.05）。结论：CVC-RBFI在ICU CVC-RBI中占重要地位，应针对危险因素进行综合防治。

关键词: 中心静脉置管, 真菌, 血流感染, 危险因素

Abstract: Objective：To investigate the pathogen epidemiology and risk factors of central venous catheter related bloodstream fungal infection (CVC-RBFI) in intensive care unit（ICU）, in order to provide useful information for the prevention and treatment of CVC-RBFI. Methods：The clinical data of 20 cases patients with CVC-RBFI in ICU between July 2006 and December 2010 were retrospectively analyzed, and compared with the control which the clinical data of 35 cases patients with central venous catheter related bloodstream bacteria infection (CVC-RBBI) at the same time. Meanwhile the pathogen epidemiology and drug resistance also were analyzed. Results：CVC-RFBI accounted for 36.36%（20/55）of central venous catheter related bloodstream infection(CVC-RBI). Non-albicans candida accounted for 60%（12/20）of fungal pathogen. The susceptibility rates of non-albicans candida to zole were 50.00%. The independent risk factors of CVC-RBFI were the existing more drainage tubes of body（OR= 8.938，P<0.05）and post major operations（OR= 11.250，P<0.05）. Conclusion： CVC-RFBI is the main party of CVC-RBI in ICU. It would be strengthened to prevent and treat to the risk factors of CVC-RBFI synthetically.

Key words: central venous catheter, fungal, bloodstream infection, risk factors