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慢性乙型肝炎患者HBV DNA水平的影响因素分析

朱复生   

  1. 大港油田总医院
  • 收稿日期:2011-03-02 修回日期:2011-04-19 出版日期:2011-09-15 发布日期:2011-09-15
  • 通讯作者: 朱复生

Correlation of serum HBV DNA levels with HDL-C in patients with chronic hepatitis B infection

  • Received:2011-03-02 Revised:2011-04-19 Published:2011-09-15 Online:2011-09-15

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摘要： 目的 本研究旨在探讨慢性乙肝患者宿主高密度脂蛋白胆固醇(HDL-C)水平与乙肝病毒(HBV) DNA水平的相关性。方法 该研究共纳入156名慢性乙肝患者，我们检测所有患者的血脂水平及HBV DNA水平。并按照HBV DNA水平将所有患者分为高病毒载量组(>107拷贝/ml, n=76)，中病毒载量组(106~105拷贝/ml, n=42)及低病毒载量组(<105拷贝/ml, n=38)。结果 慢性乙肝患者血清HDL-C水平随着病毒载量的增加而降低(P<0.01)， HDL-C水平与HBV DNA水平呈显著负相关(r=?0.336，P<0.01)。结论 慢性乙肝患者血清HDL-C水平与宿主血清HBV DNA水平呈显著负相关，HDL可能是影响HBV复制和生物学活性的重要的宿主因素，HDL-C水平可以成为预测慢性乙肝患者HBV DNA复制情况的重要血清学指标。

关键词: 乙型肝炎, 乙型肝炎病毒, 高密度脂蛋白

Abstract: Abstract Objectives The aim of the present study was to determine the correlation between high density lipoprotein cholesterol (HDL-C) levels and serum hepatitis B virus (HBV) DNA levels in patients with chronic hepatitis B infection. Methods 156 patients with chronic hepatitis B infection were enrolled in this study. Serum lipid profiles and HBV DNA levels were measured. All the patients were divided into three groups according to the HBV DNA levels: High-DNA levels group (>107copy/ml, n=76), Medium-DNA levels group (106~105copy/ml, n=42) and Low-DNA levels group (<105copy/ml, n=38). Results A significant negative correlation was found between increments in serum HBV DNA levels and HDL-C levels (P<0.01). HDL-C levels were inversely associated with HBV DNA levels (r=?0.336, P<0.01). Conclusions HDL-C levels in patients with chronic hepatitis B infection were inversely associated with disease severity of OA. These results demonstrated that HDL might affect the bioactivity and the ongoing replication of HBV, and HDL-C levels could be used as a biochemical marker for assessing the replication of HBV.

Key words: hepatitis B, hepatitis B virus, high density lipoprotein cholesterol