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容积二氧化碳图在特发性肺纤维化患者中的改变

田立芝   

  1. 天津市胸科医院肺功能科
  • 收稿日期:2010-11-18 修回日期:2011-02-23 出版日期:2011-10-15 发布日期:2011-10-15
  • 通讯作者: 田立芝

The changes of volumetric capnography in patients with Idiopathic pulmonary fibrosis

  • Received:2010-11-18 Revised:2011-02-23 Published:2011-10-15 Online:2011-10-15

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摘要： 【摘要】 目的 探讨容积二氧化碳图（VCap）在特发性肺纤维化患者中的改变特征。方法 分别对35例特发性肺纤维化患者及38例健康对照者进行常规通气功能、弥散功能及Vcap测定。采用SPSS11.0统计软件对测定结果进行统计学分析。结果 IPF组VC、DLCO均明显低于正常对照组，p＜0.01；FEV1%与正常组无差别，呈限制性通气功能障碍和弥散功能障碍。VCap参数Ⅱ期斜率较正常组无差别，p＞0.05；VT明显低于正常组，p＜0.01；VDB/VT及Ⅲ期斜率明显高于正常，p＜0.01；VDB略高于正常，p＜0.05。FEV1%与VCap各参数间均无明显相关性，；VC、DLCO均与VT成明显正相关，与VDB/VT、Ⅲ期斜率呈明显负相关，p＜0.01，与VBD和Ⅱ期斜率无相关性，p＞0.05。 结论 特发性肺纤维化患者容积二氧化碳图的改变表现为：VT降低；VDB增大；VDB/VT增高；Ⅱ期斜率正常；Ⅲ期平台消失、斜率明显增大。

关键词: 特发性肺纤维化, 呼吸功能试验, 容积二氧化碳图

Abstract: Abstract Objective:To investigate the changes of volumetric capnography(VCap) in patients with Idiopathic pulmonary fibrosis. Methods: Ventilatory function, diffusing capacity and Vcap were determined in 35 patients with idiopathic pulmonary fibrosis and 38 healthy controls.SPSS11.0 were used for statistical analysis. Results： IPF group showed restrictive ventilation and reduced diffusion capacity; VC, DLCO were significantly lower than the controls( p <0.01). VCap parameters of the slope than in normal group Ⅱ no difference, p> 0.05; VT was significantly lower than the normal group, p <0.01; VDB / VT and the slope was significantly higher than in stage Ⅲ, p <0.01; VDB slightly higher than normal, p < 0.05. FEV1% and VCap parameters showed no significant correlation; VC, DLCO were significantly positively correlated with the VT, with the VDB / VT, Ⅲ of the slope was significantly negative correlation, p <0.01, with VBD and Ⅱ was no correlation of the slope, p> 0.05. Conclusions：Patients with idiopathic pulmonary fibrosis, changes in volumetric capnography showed: VT decreased; VDB increases; VDB / VT increased; Ⅱ on the slope of the normal; Ⅲ disappearance of the platform, the slope increased significantly.

Key words: Idiopathic pulmonary fibrosis, respiratory function tests, volumetric capnography