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容积二氧化碳图在特发性肺纤维化患者中的改变

田立芝   

  1. 天津市胸科医院肺功能科
  • 收稿日期:2010-11-18 修回日期:2011-02-23 出版日期:2011-10-15 发布日期:2011-10-15
  • 通讯作者: 田立芝

The changes of volumetric capnography in patients with Idiopathic pulmonary fibrosis

  • Received:2010-11-18 Revised:2011-02-23 Published:2011-10-15 Online:2011-10-15

摘要: 【摘要】 目的 探讨容积二氧化碳图(VCap)在特发性肺纤维化患者中的改变特征。方法 分别对35例特发性肺纤维化患者及38例健康对照者进行常规通气功能、弥散功能及Vcap测定。采用SPSS11.0统计软件对测定结果进行统计学分析。结果 IPF组VC、DLCO均明显低于正常对照组,p<0.01;FEV1%与正常组无差别,呈限制性通气功能障碍和弥散功能障碍。VCap参数Ⅱ期斜率较正常组无差别,p>0.05;VT明显低于正常组,p<0.01;VDB/VT及Ⅲ期斜率明显高于正常,p<0.01;VDB略高于正常,p<0.05。FEV1%与VCap各参数间均无明显相关性,;VC、DLCO均与VT成明显正相关,与VDB/VT、Ⅲ期斜率呈明显负相关,p<0.01,与VBD和Ⅱ期斜率无相关性,p>0.05。 结论 特发性肺纤维化患者容积二氧化碳图的改变表现为:VT降低;VDB增大;VDB/VT增高;Ⅱ期斜率正常;Ⅲ期平台消失、斜率明显增大。

关键词: 特发性肺纤维化, 呼吸功能试验, 容积二氧化碳图

Abstract: Abstract Objective:To investigate the changes of volumetric capnography(VCap) in patients with Idiopathic pulmonary fibrosis. Methods: Ventilatory function, diffusing capacity and Vcap were determined in 35 patients with idiopathic pulmonary fibrosis and 38 healthy controls.SPSS11.0 were used for statistical analysis. Results: IPF group showed restrictive ventilation and reduced diffusion capacity; VC, DLCO were significantly lower than the controls( p <0.01). VCap parameters of the slope than in normal group Ⅱ no difference, p> 0.05; VT was significantly lower than the normal group, p <0.01; VDB / VT and the slope was significantly higher than in stage Ⅲ, p <0.01; VDB slightly higher than normal, p < 0.05. FEV1% and VCap parameters showed no significant correlation; VC, DLCO were significantly positively correlated with the VT, with the VDB / VT, Ⅲ of the slope was significantly negative correlation, p <0.01, with VBD and Ⅱ was no correlation of the slope, p> 0.05. Conclusions:Patients with idiopathic pulmonary fibrosis, changes in volumetric capnography showed: VT decreased; VDB increases; VDB / VT increased; Ⅱ on the slope of the normal; Ⅲ disappearance of the platform, the slope increased significantly.

Key words: Idiopathic pulmonary fibrosis, respiratory function tests, volumetric capnography