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丝裂霉素C在单切口晶状体超声乳化联合小梁切除术中的应用

丁娟,马伊,张岩   

  1. 天津市眼科医院
  • 收稿日期:2011-10-27 修回日期:2012-05-01 出版日期:2012-10-15 发布日期:2012-10-15
  • 通讯作者: 马伊

Clinical Observation of the MMC on One-site Phacotrabeculectomy

  • Received:2011-10-27 Revised:2012-05-01 Published:2012-10-15 Online:2012-10-15

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摘要： 摘要 目的：评价丝裂霉素C（MMC）应用于慢性闭角型青光眼(PACG)患者行青光眼白内障联合手术中的价值。方法：选取PACG合并白内障患者33例（33眼），分为使用MMC组（14眼）及对照组（19眼），对2组行晶状体超声乳化、人工晶体植入联合小梁切除术，比较2组手术前后视力、眼压、并发症以及滤过泡情况。结果：2组术后最佳矫正视力及眼压均较术前都较大改善。12周时MMC组的眼压低于对照组(P<0.05)。MMC组滤过泡的生存时间与对照组差异无统计学意义(P>0.05)。2组术后并发症相似，均未发生较严重并发症。结论：晶状体超声乳化联合小梁切除术中使用MMC有助于控制术后眼压水平。

关键词: 丝裂霉素类, 超声乳化白内障吸除术, 小梁切除术, 青光眼, 闭角型

Abstract: Objective：To evaluate the early effects of mitomycin C（MMC）on combined phacoemulsification, posterior chamber intraocular lens implantation, and trabeculectomy (phacotrabeculectomy) in patients with primary angle closure glaucoma (PACG).Methods：Thirty-three(thirty-three eyes) patients who were dignosed with PACG combined with catract were randomly divided into two groups ,MMC group(fourteen eyes) and control group(nineteen eyes).All the cases were treated with phacotrabeculectomy.Visual acuity, intraocular pressure (IOP), and complications and bleb survival probability were evaluated.Results：The best corrected visual acuity（BCVA）improved and mean IOP decreased significantly after phacotrabeculectomy in both groups. The mean IOP reduction was significantly greater in eyes with MMC group in 12w.(P <0.05). The bleb survival probability in MMC group was higher than control group,but was not significant (P>0.05).The early postoperative complication rates were similar in both groups.Conclusion：Phacotrabeculectomy with MMC results in greater IOP reduction which can be effective method in controlling intraocular pressure level.

Key words: MMC, Phacoemulsification trabeculectomy glaucoma angle-closure