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盐酸度洛西汀对抑郁相关疼痛障碍疗效的研究

龙鲸   

  1. 天津市安定医院
  • 收稿日期:2011-02-01 修回日期:2011-04-12 出版日期:2011-08-15 发布日期:2011-08-15
  • 通讯作者: 龙鲸

Effect of DuIoxetine on treating depression with chronic pain

  • Received:2011-02-01 Revised:2011-04-12 Published:2011-08-15 Online:2011-08-15

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摘要： 【摘要】 目的 探讨度洛西汀治疗以疼痛为主诉的抑郁障碍的疗效和安全性。方法 对60例以疼痛为主诉的抑郁障碍患者给予8周度洛西汀治疗。分别于治疗前和治疗后2，4，6，8周对患者进行汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、副反应量表(TESS)、视觉模拟(VAS)评分、生存质量评定量表(WHOQOL)的评定和相关实验室检查。结果 治疗后患者HAMD、HAMA、VAS评分比入组时明显降低(P<0.01)；患者用药期间未出现明显的药物不良反应；患者生活质量中的生理、心理、独立性3个领域有明显改善。结论 度洛西汀能有效改善以疼痛为主诉的抑郁障碍患者的抑郁、焦虑、疼痛症状，不良反应轻微，能明显提高患者的生活质量。

关键词: 度洛西汀, 抑郁症, 慢性疼痛

Abstract: 【Abstract】Objective: To study the effect and reliability of Duloxetine in the treatment of Depression with chronic pain. Methods: 60 cases of depressive disorders with pain were treated by Duloxetine for 8 weeks,at the same time，their emotion state,change of life quality,adverse effect,the remission of pain with HAMD、HAMA、WHOQOL、TESS、VAS and laboratory tests were evaluated.Results: After 8 weeks,patients’ scores of depression 、anxiety and pain decreased significantly from the baseline(p<0.01).Three domains of life quality (physiology，psychoLogy and independence) became much better than those of baseline(p<0.05). Conclusion: Duloxetine can reduce the depression、anxiety and pain ,improve the patients’ quality of Iife.

Key words: Duloxetine, Depressin, Chronicpain