天津医药

• 实验研究 • 上一篇    下一篇

超声造影评价肝肿瘤射频治疗疗效的实验研究

丁建民1,经翔2   

  1. 1. 天津市第三中心医院
    2. 天津市第三中心医院超声科
  • 收稿日期:2010-10-29 修回日期:2011-01-07 出版日期:2011-07-15 发布日期:2011-07-15
  • 通讯作者: 丁建民

The Experimental Study of Contrast Enhanced Ultrasonography Assessingthe Effect of Treating Hepatic Tumor with Radiofrequency Ablation

  • Received:2010-10-29 Revised:2011-01-07 Published:2011-07-15 Online:2011-07-15

PDF (PC)

1911

摘要： 摘要 目的:分析兔肝VX2肿瘤射频消融（RFA）后超声造影（CEUS）与增强CT（CECT）、病理之间的相关性，验证CEUS评价RFA疗效的可靠性。方法：建立兔肝VX2肿瘤模型进行RFA治疗。RFA后1周行CEUS、CECT及病理学检查，对3种检查方法的结果进行比较。结果：30只瘤兔30个肿瘤RFA后22个残留，8个完全消融。CEUS测得消融灶的平均最大径、垂直径和面积分别为1.37±0.34cm、1.02±0.37cm和1.52±0.90cm；CECT的测值为1.32±0.37cm、0.95±0.37cm和1.38±0.88cm；病理标本测值为1.27±0.35cm、0.94±0.34cm和1.31±0.77cm。以病理结果为标准，CEUS与CECT诊断残瘤的敏感性、特异性和准确性分别为90.9％、75.0％、86.7％和86.4％、87.5％、86.7％。结论：CEUS对微血管具有高度敏感性，RFA后能较准确地判断毁损区的范围，识别残存肿瘤，为肝癌的后续治疗提供可靠依据。

关键词: 超声检查, 造影剂, 射频消融, VX2肿瘤, 体层摄影术, X线计算机

Abstract: Abstract Objective: To analyze the correlation with contrast enhanced ultrasonography (CEUS), contrast enhanced CT (CECT) and histopathology through observing the findings of hepatic VX2 tumor in rabbits after RFA on CEUS, CECT and histopathology, and explore the reliability of CEUS in assessing the response of hepatic tumors after RFA. Methods: RFA was applied to rabbit hepatic VX2 tumors. Both CEUS and CECT were performed 1 week after RFA in rabbit models with hepatic VX2 tumor and followed with histopathologic examination. The results of CEUS, CECT and histopathologic examinations were compared. Results: Residual viable tumors were found in 22 models and no residual tumors were seen in 8 models after RFA according to histopathology. The average largest diameter and perpendicular diameter and area of ablation areas were 1.37±0.34 cm, 1.02±0.37 cm and 1.52±0.90 cm on CEUS, respectively. Those of ablation areas were 1.32±0.37 cm, 0.95±0.37 cm, 1.38±0.88 cm and 1.27±0.35 cm, 0.94±0.34 cm, 1.31±0.77 cm on CECT and sample, respectively. According to the results of histopathology, the sensitivity, specificity and accuracy for evaluating therapeutic effect were 90.9％, 75.0％, 86.7％ for CEUS and 86.4％, 87.5％, 86.7％ for CECT, respectively. Conclusion: CEUS is sensitive to capillary vessel. It can accurately discriminate the coagulation necrosis from residual tumors after RFA and offer the reliable foundation for subsequent treatment.

Key words: Ultrasonography, Contrast agent, Radiofrequency ablation, VX2 tumor, Tomography, X-ray computed