根除幽门螺杆菌前后胃窦粘膜环氧化酶-2表达的变化

根除幽门螺杆菌前后胃窦粘膜环氧化酶-2表达的变化

王琳

天津医科大学总医院

收稿日期:2010-10-22 修回日期:2011-01-10 出版日期:2011-05-15 发布日期:2011-05-15
通讯作者: 王琳

The change of cyclooxygenase-2 expression in gastric antral mucosa before and after eradication of Helicobacter pylori

Received:2010-10-22 Revised:2011-01-10 Published:2011-05-15 Online:2011-05-15

王琳. 根除幽门螺杆菌前后胃窦粘膜环氧化酶-2表达的变化[J]. .

摘要/Abstract

摘要： 目的检测根除Hp前后胃窦粘膜中环氧化酶-2(Cyclooxygenase-2，COX-2)表达水平的变化，探讨COX-2表达与慢性胃炎的关系。方法对我院2007，7—2O09，3胃镜检查诊断为慢性胃炎,快速尿素酶和14C尿素呼气试验均证实Hp阳性的15例住院病人，根除Hp前后分别取胃窦粘膜组织活检，HE染色显示组织结构和炎性细胞浸润情况，用免疫组化学方法显示COX-2表达情况。结果慢性胃炎的胃窦上皮细胞和壁细胞、单核细胞均可检测到COX-2的表达，根除Hp后，COX-2的表达明显减少 (P

关键词: 慢性胃炎, 幽门螺杆菌, 环氧合酶-2

Abstract: Abstract Aim To discuss the expression of COX-2 in the antral mucosa of pations before and after eradication of Hp infection. And the relation of this expression with chronic infectionMethod Tissues were obtained from chronic gastritis patients with Hp infection and subsequent eradication were studied. Three biopsies of antral mucosa were evaluated before and after Hp eradication. Immumohistochemical staining for COX一2 was expressed as a percentage of the total number of cells and correlated with the degree of chronic inflammation． Result C0X -2 expression could be detected before and after eradication of Hp．The expression of COX-2 was significantly higher in Hp infected mucosa compared with that Hp has been successfully eradicated(P<0．005)．The positive immunostaining of COX-2 correlated closely with the chronic inflammation score(r=0．59，P<0．05). Conclusion The overexpression of COX-2 may be one of the crucial mechanisms of Hp induced gastritis．

Key words: gastritis, Helicobacter pylori, Cyclooxygenase-2

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