天津医药

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多囊卵巢综合征患者抗苗勒氏管激素与相关临床指标的关系

徐燕颖1,尹利荣2,陈逢振1,王莉1,杨维娜1   

  1. 1. 天津医科大学第二医院
    2. 天津医科大学第二医院妇科
  • 收稿日期:2012-07-24 修回日期:2012-12-27 出版日期:2013-02-15 发布日期:2013-02-15
  • 通讯作者: 徐燕颖

Relationship between plasma anti-Müllerian hormone (AMH) level and body weight, metabolic,and hormonal status in women with polycystic ovary syndrome

XU Yan ying1,YIN Li rong2,CHEN Feng zhen1,WANG LI 3, 3   

  1. 1. Department of Gynecology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China
    2. Department of Gynecology, The Second Hospital of Tianjin Medical University
    3.
  • Received:2012-07-24 Revised:2012-12-27 Published:2013-02-15 Online:2013-02-15
  • Contact: XU Yan ying

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摘要：

【摘要】目的 探讨多囊卵巢综合征（PCOS）患者抗苗勒氏管激素（AMH）水平与体质指数（BMI）、激素及代谢指标的关系。方法 将60例PCOS患者和30例不孕患者分为PCOS组1（BMI≥25 kg/m2）、PCOS组2（BMI<25 kg/m2），每组30例；对照组1（BMI≥25 kg/m2）、对照组2（BMI<25 kg/m2），每组15例。空腹采血并测定血清卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇、睾酮、血清AMH、空腹血糖和空腹血清胰岛素，计算稳态模型胰岛素抵抗指数（HOMA-IR），比较4 组的上述指标并进行相关性分析。结果 PCOS 组AMH、LH、LH/FSH、睾酮、空腹胰岛素及 HOMA-IR均高于对照组，PCOS组1和PCOS组2 AMH差异无统计学意义，PCOS组1 LH、LH/FSH低于PCOS组2，空腹胰岛素、HOMA-IR高于PCOS组2。PCOS组AMH与BMI无相关性。PCOS组1 AMH与睾酮、空腹血糖、空腹胰岛素、 HOMA-IR呈正相关，与雌二醇、FSH呈负相关；PCOS组2 AMH与LH、LH/FSH、睾酮呈正相关（均P < 0.05）。结论 PCOS患者血清AMH显著升高，其升高与体质量无关，可能与激素紊乱和糖代谢紊乱有关。

关键词: 多囊卵巢综合症, 抗苗勒氏管激素, 高雄激素, 胰岛素抵抗

Abstract:

[Abstract] Objective  To analyze interrelation between anti-Müllerian hormone (AMH) levels and body weight，hormone status and metabolic rate in women with polycystic ovary syndrome (PCOS). Methods  Sixty women (30 normal weight, PCOS 1 group and 30 overweight, PCOS 2 group) diagnosed as PCOS were enrolled and 30 healthy women (15 normal weight and 15 overweight non-PCOS) were as control group．The body weight and height were measured and body mass index(BMI) was calculated. The serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, testosterone, adrenal medullary hormone (AMH), androgens, fasting glucose and fasting insulin were detected, and the homeostasis model of assessment-insulin resistance (HOMA-IR) were caculated and compared between four groups. Results  The levels of AMH, LH, LH/FSH, testosterone, fasting insulin and HOMA-IR were higher in PCOS group than those of control group. There was no significant difference in AMH level between PCOS 1 and PCOS 2 groups. The levels of LH and LH/FSH were lower in PCOS 1 group than those of PCOS 2 group. The levels of fasting insulin and HOMA-IR were higher in PCOS 1 group than those of PCOS 2 group. There were no correlations in AMH and BMI levels in PCOS group. There were positive correlations in AMH and testosterone, fasting glucose and fasting insulin and HOMA-IR in PCOS 1 group，but a negative correlation between estradiol and FSH. A significant positive correlation was found between LH, LH/FSH, testosterone and AMH in PCOS 2 group (P < 0.05). Conclusion  There is a significant increase in plasma AMH in patients with PCOS. The plasma AMH level is not associated with BMI, which may have correlation with hormone imbalance and metabolic disorders.

Key words: polycystic ovary syndrome, anti-Müllerian hormone, hyperandrogenism, insulin resistance