天津医药

• 论著 • 上一篇    下一篇

局部亚低温治疗对急性大面积脑梗死患者血浆PAF的影响

侯丹,余丹   

  1. 海南省海口市人民医院
  • 收稿日期:2012-03-27 修回日期:2012-09-07 出版日期:2013-02-15 发布日期:2013-02-15
  • 通讯作者: 余丹

Effects of Local Mild Hypothermia Therapy On Serum Content of Platelet Activating Factor in Patients with Acute Large Area Cerebral Infarction

HOU Dan ,YU Dan   

  1. Department of Neurology, Affiliated Haikou Hospital of Xiangya Medical School，Central South University, Haikou 570000, China
  • Received:2012-03-27 Revised:2012-09-07 Published:2013-02-15 Online:2013-02-15
  • Contact: YU Dan

PDF (PC)

2352

摘要：

【摘要】目的 观察局部亚低温治疗急性大面积脑梗死患者的临床疗效和血清血小板活化因子（PAF）水平，探讨局部亚低温治疗脑梗死的临床意义及脑保护作用机制。方法 将发病24 h内入院的急性大面积脑梗死患者50例随机分为亚低温组及常规治疗组，亚低温组在常规药物治疗的基础上加用局部亚低温脑保护仪治疗48 h，并在治疗前及治疗48 h后采用美国国立卫生研究院卒中量表（NIHSS）进行神经功能缺损评分，采用酶联免疫吸附法测定治疗前后血清PAF水平。结果 治疗前，2组血清PAF活性及NIHSS评分差异无统计学意义，治疗48 h后，亚低温治疗组的PAF的活性（151.9±10.8），NIHSS评分（24.0±4.8），分别低于常规治疗组的（163.7±12.8）和（29.6±6.7），差异均有统计学意义（P﹤0.05）。结论 贴敷式局部亚低温治疗能促进急性大面积脑梗死患者神经功能恢复，其脑神经保护作用机制可能是亚低温影响PAF活性。

关键词: 亚低温, 大面积脑梗死, 血小板活化因子, 神经功能评分.

Abstract:

[Abstract] Objective  To observe the clinical effects and changes of serum activity of platelet activating factor (PAF) of mild hypothermia therapeutic (MHT) in patients with massive cerebral infarction, and the mechanisms thereof. Methods  Fifty patients with acute massive cerebral infarction diagnosed within 24 hours were randomly divided into hypothermia therapy group and conventional treatment group. The hypothermia therapy group accepted conventional treatment and hypothermia therapy for 48 hours. The neural function deficiency scores and the serum activity of PAF were compared before treatment and 48 hours after treatment. The U.S. National Institutes of Health Stroke Scale (NIHSS) was used to measure the neural function deficiency. Enzyme linked immunosorbent assay was used to detect the serum activity of PAF. Results  After 48- hour treatment，there were significant differences in the PAF activity and NIHSS scores between hypothermia group and conventional treatment group (P﹤ 0.05). Conclusion  The local mild therapeutic hypothermia can obviously improve the neurological function in patients with acute massive cerebral infarction, which may be involved in the decreased activity of serum PAF.

Key words: Hypothermia, Massive cerebral infarction, Platelet Activating Factor, Neural Function Deficiency Scores.