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不同性别T2DM患者血清γ-GGT水平与心血管危险因素的相关性

欧倩滢1,赵伟2,张雅静1,陈碧霄3,姜春艳3,张宏2   

  1. 1. 天津医科大学代谢病医院
    2. 天津医大代谢病医院
    3. 天津医科大学代谢病医院 卫生部及天津市激素与发育重点实验室
  • 收稿日期:2012-02-15 修回日期:2012-09-02 出版日期:2013-02-15 发布日期:2013-02-15
  • 通讯作者: 欧倩滢

Correlation between Serum γ-GGT Level and Cardiovascular Risk Factors in Different Genders with Type 2 Diabetes Mellitus

  • Received:2012-02-15 Revised:2012-09-02 Published:2013-02-15 Online:2013-02-15
  • Contact: OU Qian ying

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摘要：

目的 探讨不同性别的2型糖尿病（T2DM）患者血清谷氨酰转移酶（γ-GGT）水平与多种心血管危险因素之间的相关性。方法 286例T2DM患者先按性别分组，再按γ-GGT四分位数分组。比较各组间体质指数（BMI）、腰围、血压、肝功能全项、血脂、血糖等生化指标。结果 不同性别的T2DM患者BMI、腰围、舒张压（DBP）、三酰甘油（TG）、尿酸（UA）、γ-GGT、年龄、高密度脂蛋白胆固醇（HDL-C）、糖化血红蛋白（HbA1c）、高敏C反应蛋白（hsCRP）以及血浆纤维蛋白原（FIB）水平差异有统计学意义。γ-GGT水平不同时，男性的年龄、病程、BMI、腰围、收缩压（SBP）、 DBP、TG、总胆固醇（TC）、丙氨酸转氨酶（ALT）以及天冬氨酸转氨酶（AST）水平差异有统计学意义，女性的腰围、TC、 LDL-C、hsCRP、ALT、AST以及碱性磷酸酶（ALP）水平差异有统计学意义；男性γ-GGT与年龄和病程呈负相关，与 BMI、腰围、DBP、TG、TC、hsCRP及UA呈正相关，女性γ-GGT与腰围、TC、低密度脂蛋白胆固醇（LDL-C）、HbA1c、 hsCRP及UA呈正相关；BMI和TC升高是男性γ-GGT的独立危险因素，腰围大和hsCRP高是女性γ-GGT的独立危险因素。结论 T2DM患者血清γ-GGT与多种心血管危险因素相关，其对糖尿病患者心血管并发症的预示作用值得重视和研究。

关键词: 糖尿病, 2型, 危险因素, 血脂异常, 高敏C反应蛋白, γ-谷氨酰转移酶

Abstract:

[Abstract] Objective  To explore the correlation between serum gamma glutamyltransferase (γ-GGT) and cardio vascular risk factors in different genders with type 2 diabetes mellitus. Methods  A total of 286 patients with type 2 diabetes were divided into male group and female group, and then each group was sub-divided into four groups according to the quartile of serum γ-GGT level. The values of body mass index (BMI), waist, systolic pressure (SBP), diastolic pressure (DBP), triglyceride (TG), cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), high sensitive c-reactive protein (hsCRP) and uric acid (UA) were compared between groups. Results  There were significant differences in BMI, waist, DBP, TG, TC, UA，γ-GGT，age, HDL-C，HbA1c，hsCRP and plasma fibrinogen (FIB) between different genders with type 2 diabetes mellitus. There were significant differences in age，duration of disease，BMI, waist, SBP, DBP, TG, TC, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in male subjects with different γ-GGT levels. There were significant differences in waist, TC, LDL-C, hsCRP, ALT,AST and alkaline phosphatase (ALP) in female. The level of γ-GGT was negatively correlated with age and duration of disease in male patients. But it was positively correlated with BMI, waist, DBP, TG, TC, hsCRP and UA in male patients. In female patients, the level of γ-GGT was positively correlated with waist, TC, LDL-C, HbA1c, hsCRP and UA. Values of BMI and TC were the independent risk factors of γ-GGT in male patients. Values of waist and hsCRP were the independent risk factors of γ-GGT in female patients. Conclusion  The serum γ-GGT is closely related with several cardiovascular risk factors in patients with type 2 diabetes mellitus, which deserves attention and research in predicting the cardiovascular complication of diabetes.

Key words: diabetes mellitus, type 2, risk factor, dyslipidemias, high sensitive c-reactive protein, gamma glutamyltransferase