天津医药

• 论著 •    

影响老年患者血浆 D-二聚体水平的相关因素分析

郭世杰1,吴存瑾1,王林2,杨丽敏1,马金萍2   

  1. 1. 天津医科大学第二医院干部保健科
    2. 天津医科大学第二医院
  • 收稿日期:2012-09-03 修回日期:2012-12-16 出版日期:2013-07-15 发布日期:2013-07-15
  • 通讯作者: 郭世杰

The Correlative Factors Affecting Elderly Patients’Plasma D-dimer Level.

GUOShi-Jie 1,WU Cunjin 1,WANG Lin2,YANG Limin 1,MA JIN PING2   

  1. 1. The Second Hospital of Tianjin Medical University, Tianjin 300211, China
    2. Department of Gerontology, the Second Hospital of Tianjin Medical University, Tianjin 300211, China
  • Received:2012-09-03 Revised:2012-12-16 Published:2013-07-15 Online:2013-07-15
  • Contact: GUOShi-Jie

PDF (PC)

2468

摘要：

【摘要】 目的  探讨影响老年患者血浆D-二聚体水平的相关因素。方法  入选老年住院患者578例,自动化定量乳胶凝聚比浊法测定血浆D-二聚体水平,根据其检测结果分为正常组(<0.4mg/L)和升高组(≥0.4mg/L),比较2组间主要临床指标的差异,并分析引起D-二聚体水平升高的影响因素。结果  升高组患者的年龄、C反应蛋白水平、凝血酶原时间、2型糖尿病、恶性肿瘤及细菌性肺炎和(或)慢性支气管炎急性发作的发生比例均高于正常组,而总胆固醇及低密度脂蛋白胆固醇水平则低于正常组(P<0.05)。血浆D-二聚体水平与年龄、C反应蛋白呈正相关(r分别为0.254、0.265,均P<0.05)。年龄增长、CRP升高,及存在恶性肿瘤、2型糖尿病、细菌性肺炎和(或)慢性支气管炎急性发作是引起老年患者血浆D-二聚体水平升高的影响因素。结论   高龄,存在2型糖尿病、恶性肿瘤和(或)急性炎症状态是引起老年患者血浆D-二聚体水平升高的重要因素。 

关键词: C反应蛋白, 凝血酶原时间, 糖尿病, 2型, 肿瘤, 炎症, 脂类, 老年人

Abstract: Objective  To Research on the risk factors of plasma D-dimer levels in hospitalized elderly patients with internal medicine disease. Methods   Five hundred and seventy eight hospitalized elderly patients were collected from the policlinic for old cadre’s veteran carder clinic of The Second Hospital of Tianjin Medical University. The subjects’ plasma D-dimer was measured by Automatic quantitate latex agglutination rates assay. Subjects were divided into 2 groups: the normal group (less than 0.4 mg / L), and the elevated group (greater than equal to 0.4 mg / L). Record the results of CRP, blood glucose and coagulation conventional test, and the history of diabetes, malignancies and bacterial pneumonia and (or) acute exacerbation of chronic bronchitis of each object. Results    the average value of age, CRP, aPTT, and PT, the rate of diabetes, malignance, and bacterial pneumonia and (or) acute exacerbation of chronic bronchitis in the elevated group were statistically higher than the normal group, but the average value of TC and LDL were statistically lower than the normal group（P<0.05). the plasma D-dimer level had a significant positive correlation with the patient’s age, CRP, diabetes, malignance, and bacterial pneumonia and (or) acute exacerbation of chronic bronchitis (P<0.05). The result of Binary logistic regression analysis showed that age, CRP, diabetes, malignance, and bacterial pneumonia and (or) acute exacerbation of chronic bronchitis (P<0.05). Conclusion   Aging, diabetes, malignance, and acute inflammatory state were the important factors to lead elderly patients’ plasma D-dimer levels to elevate.

Key words: C-reactive protein, prothrombin time, diabetes mellitus, type 2, tumor, inflammation, lipids, 老年人