天津医药

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Ang-2在大肠癌中的表达及其与病理和临床特征的关系

马志兰   

  1. 宁夏医科大学2009级研究生3班
  • 收稿日期:2011-05-25 修回日期:2011-08-17 出版日期:2012-03-15 发布日期:2012-03-15
  • 通讯作者: 马志兰

Expression of angiopoietin-2 with the relationship between pathology and clinical features in colorectal carcinoma

zhilan-Ma   

  • Received:2011-05-25 Revised:2011-08-17 Published:2012-03-15 Online:2012-03-15
  • Contact: zhilan-Ma

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摘要： 摘要:目的 研究血管生成素2(Ang-2)蛋白在大肠癌组织中的表达及其与病理和临床特征的关系。方法 应用免疫组化法检测54例大肠癌组织、18例癌旁正常组织及20例大肠良性病变组织中Ang-2的表达水平。结果 Ang-2在大肠癌组织、癌旁正常组织及大肠良性病变组织中阳性表达率分别为77.78%、27.78%和30.00%；癌组织与癌旁正常组织、良性病变组织相比，均有统计学差异(??分别为14.890、14.618，P<0.05)； Ang-2阳性表达率与大肠癌浸(P<0.05)，与患者性别、年龄、民族、职业、良性疾病史、肿瘤家族史、肿瘤部位、大小和分化润深度、淋巴结转移、远处转移及临床分期呈正相关(r分别为0.490、0.337、0.338、0.386，程度均无关(P>0.05)。结论 Ang-2蛋白高表达可能在大肠癌的发生、发展、侵袭和转移中发挥重要的作用。

关键词: 大肠癌, 血管生成素2, 免疫组织化学

Abstract: Abstract :Objective To study the expression of Angiopoietin-2(Ang-2)protein in colorectal carcinoma and evaluate the relationship between Ang-2 protein level and pathology and clinical features. Methods Expression of Ang-2 was examined in 54 patients with colorectal carcinoma and 18 patients with adjacent normal tissues and 20 patients with normal tissues with immunohistochemical technique. Results The positive rate were 77.78%、27.78%和30.00%；Compared the expressions of Ang-2 in colorectal carcinoma tissue with adjacent normal tissue and benign colorectal lesion tissue, there were all significant differences (??=14.890,14.618,P<0.05); The positive expression rates of Ang-2 were significantly correlated with depth of invasion, lymph node metastasis, distant metastasis and clinical stage (r=0.490,0.337,0.338,0.386, P<0.05) in carcinoma patients;With sex,age,nationality,occupation,history of benign desease and family history of cancer,tumor location ,size and degree of differentiation were not related(P>0.05). Conclusion Expression of Ang-2 protein in colorectal cancer may occur in the development ,invasion and metastasis play an important role.

Key words: colorectal carcinoma, Angiopoietin-2, immunohistochemical technique