天津医药

• 应用研究 • 上一篇    下一篇

老年急性脑梗死患者血浆8-异前列腺素F2α与神经功能缺失程度的关系

郑海建1,谢燕2,张化民1,秦华1   

  1. 1. 赣榆县人民医院
    2. 苏州大学附属第一医院
  • 收稿日期:2013-08-22 修回日期:2014-02-26 出版日期:2014-07-15 发布日期:2014-07-15
  • 通讯作者: 郑海建

Correlation of Serum8-iso-PGF2αLevel and the Severity of Neurological Deficits in Elderly Patients with Cerebral Infarction

  • Received:2013-08-22 Revised:2014-02-26 Published:2014-07-15 Online:2014-07-15

PDF (PC)

2682

摘要：

【摘要】目的 探讨老年急性脑梗死患者血浆8-异前列腺素F2α（8-iso-PGF2α）的变化及与神经功能缺失程度的关系。方法将67例急性脑梗死患者分为中青年组30例（＜60岁）和老年组（≥60岁）37例，另择30例健康体检者（≥60岁）为老年对照组。采用ELISA法检测脑梗死患者血浆8-iso-PGF2α水平，采用美国国立卫生研究院脑卒中量表(NIHSS)评分进行神经功能缺损评估。结果老年组血浆8-iso-PGF2α水平(506.38±138.63)ng/L高于老年对照组(369.98±99.81)ng/L和中青年组(420.18±132.72)ng/L，中青年组与老年对照组差异无统计学意义（F=9.272，P＜ 0.05）。老年组NIHSS评分高于中青年组[ （19.78±3.66）vs（17.73±2.70），t=2.539，P＜0.05]。老年组血浆8-iso-PGF2α 与NIHSS评分呈正相关（r=0.504，P=0.001）。结论氧化应激在老年急性脑梗死患者的发生、发展过程中起着重要的作用，尽早合理的抗氧化治疗可以减轻临床症状，促进病情恢复。

关键词: 脑梗死, 氧化应激, 8-异前列腺素F2a, 老年

Abstract:

[Abstract] Objective To investigate the relationship between the level of8-iso-prostaglandin (8-iso-PG)F2αand the neural functional deficit in patients with acute cerebral infarction (ACI). Methods Sixty-seven ACI patients were se? lected in Neurological Department of Ganyu People’s Hospital. According to the age, these subjects were divided into two groups: the old group (≥60years,n=37) and middle-young group (<60years,n=30). Thirty healthy subjects were selected as controls (≥60years). The age, gender and anamnesis were matched in two groups of elderly people. The ELISA was used to detect the plasma levels of8-iso-PGF2αin two groups of patients. And NIHSS score was used to evaluate the severity of clinical neurological deficit. Results The plasma levels of8- iso- PGF2αwere significantly higher in old ACI group (506.38±138.63) ng/L than those of middle-young ACI group (420.18±132.72) ng/L and old control group (369.98±99.81) ng/L. There was no significant difference in plasma level of8-iso-PGF2αbetween middle-young ACI group and old control group (F=9.272，P＜0.05). The NIHSS score was significantly higher in old group (19.78±3.66) than that of middle-young group (17.73±2.70, t=2.539，P＜0.05). There was a positive correlation between plasma 8- iso- PGF2αlevel and NIHSS score in old group (r=0.504，P=0.001). Conclusion The oxidative stress plays an important role in the occurrence and de? velopment process of ACI in elderly patients. The earlier and reasonable antioxidant therapy plays a positive role to alleviate the clinical symptoms and promote the recovery of illness.

Key words: cerebral infarction, oxidation, 8-iso-PGF2a, old age