天津医药

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乳腺癌中人表皮生长因子受体-2的表达与血管生成的相关性

王刚1,徐卫国2,赵三平2,朱海燕3   

  1. 1. 华北煤炭医学院附属开滦医院（开滦集团有限责任公司医院）
    2. 华北煤炭医学院附属医院
    3. 华北煤炭医学院
  • 收稿日期:2010-06-07 修回日期:2010-11-23 出版日期:2011-04-15 发布日期:2011-04-15
  • 通讯作者: 王刚

The Expression of her-2 in the breast cancer and its relationship with angiogenesis

  • Received:2010-06-07 Revised:2010-11-23 Published:2011-04-15 Online:2011-04-15

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摘要： 目的：探讨人表皮生长因子受体-2（HER-2）蛋白在乳腺癌中的表达及血管生成之间的关系。方法：采用免疫组化法检测乳腺癌及癌旁组织中HER-2的表达水平及肿瘤微血管密度（MVD）。结果：乳腺癌组织中HER-2 蛋白的表达和MVD值显著高于癌旁乳腺组织（P＜0.05)；腋窝淋巴结转移组中HER-2 蛋白的表达和MVD值高于未转移组(P<0.05); 低分化组中HER-2表达水平和MVD值明显高于中、高分化组(P<0.05);Ⅲ期组中HER-2表达水平高于Ⅰ-Ⅱ期组，并且HER-2表达水平随着T分期（肿瘤大小）的进展而增高(P<0.05)。HER-2阳性组中MVD值显著高于HER-2阴性组（P＜0.05）。结论：HER-2在乳腺癌中表达上调， 其在乳腺癌的发生、发展及血管生成过程中发挥重要作用。

关键词: 乳腺肿瘤, 人表皮生长因子受体-2, 微血管密度

Abstract: Objective To study the expression of her-2 in the breast cancer and its relationship with angiogenesis. Methods The expression of her-2 and MVD were detected in 98 cases of breast cancer and 56 cases of neighboring noncancerous tissue by the method of immunohistochemistry. Results The positive rates of her-2 in breast cancer was higher than that in the neighboring noncancerous tissue（P＜0.05)； the expression of her-2 was correlated with lymph node metastasis and the difference is significant （P＜0.05)；her-2 and MVD in poorly differentiated group was significantly higher than that in well-differentiated and moderate-differentiated group（P＜0.05); her-2 was positively correlated with tumor size; her-2 expression increased with increased TNM staging(P＜0.05).;CD105-MVD in her-2 positive tumors was significant higher than in her-2 negative tumors(P＜0.05). Conclusions The Experssion of her-2 in breast cancer are up regulated, her-2 plays an important role in incidence, development and angiogenesis of breast cancer

Key words: Breast neoplasms, her-2, Microvessel density