天津医药

• 论著 • 上一篇    下一篇

神经上皮性肿瘤18F-FDG摄取水平与VEGF表达及微血管密度的相关性

蔡莉,高硕,李彦生,刘磊,杨海磊   

  1. 天津医科大学总医院
  • 收稿日期:2010-06-17 修回日期:2010-12-07 出版日期:2011-04-15 发布日期:2011-04-15
  • 通讯作者: 杨海磊

Correlation studies of 18F-FDG uptake with VEGF expression and MVD in neuroepithelioma

  • Received:2010-06-17 Revised:2010-12-07 Published:2011-04-15 Online:2011-04-15

PDF (PC)

2169

摘要： 目的: 探讨神经上皮性肿瘤18F-FDG摄取水平与血管内皮生长因子（VEGF）表达及肿瘤微血管密度（MVD）间的相关性。方法: 对41例神经上皮性肿瘤的患者行18F-FDG PET检查，肿瘤标本采用免疫组化染色，观察VEGF表达及定量研究肿瘤MVD。按VEGF表达高低分为两组，观察VEGF低表达和高表达两组间18F-FDG 的T/WM是否有统计学差异，并用非参数相关分析法观察T/WM与MVD间的相关性。结果: 41例中，VEGF低表达者24例，VEGF高表达者17例。VEGF低表达组T/WM值为0.62～3.04，中位数1.89；VEGF高表达组T/WM值为1.29～7.64，中位数3.02。两组间T/WM差异有统计学意义（P<0.05）。肿瘤MVD值为9.76～94.52，T/WM与MVD呈显著正相关性（r=0.759，P<0.05）。结论: 神经上皮性肿瘤的18F-FDG摄取水平与VEGF表达及MVD之间存在良好相关性，可用于术前活体评估肿瘤的血管生成情况，对临床选择治疗方案及评估预后具有重要意义。

关键词: 神经上皮性肿瘤, 脱氧葡萄糖, 正电子发射断层, 血管内皮生长因子, 微血管密度

Abstract: Objective: To investigate the correlation of 18F-FDG uptake with vascular endothelial growth factor (VEGF) protein expression and microvessel density (MVD) in neuroepithelioma. Methods: 18F-FDG PET examinations were performed preoperatively in 41 patients with suspected neuroepithelioma. Immunohistochemical stain methods were used to demonstrate the situation of VEGF expression and quantitatively measure the MVD in tumors. According to the situation of VEGF expression, all the cases were divided into two groups including low VEGF expression group and high VEGF expression group. Mann-Whitney U test was used for comparing the difference between the two groups. Spearman correlation analysis was used for observing the correlation between T/WM and MVD. Results: T/WM in low VEGF expression group (n=24) and high VEGF expression group (n=17) ranged from 0.62～3.04 and 1.29～7.64, respectively. The difference of T/WM between two groups was statistically significant (P<0.05). The MVD of tumors were 9.76～94.52, which showed positive correlation with T/WM (P<0.05). Conclusion: The 18F-FDG uptake of neuroepithelioma are feasible for evaluation of microvessel angiogenesis in vivo and have instructive function for clinical treatment and assessment of prognosis.

Key words: neuroepithelioma, deoxyglucose, PET, vascular endothelial growth factor, microvessel density