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非小细胞肺癌中LKB1、VEGFR2的表达及临床意义

李作生,王国臣,陈志全,郑贸根,侯静朴   

  1. 河北联合大学附属医院
  • 收稿日期:2011-11-07 修回日期:2012-02-03 出版日期:2012-07-15 发布日期:2012-07-15
  • 通讯作者: 李作生

The Expressions and Clinical Significance of LKB1 and VEGFR2 in Non-Small Cell Lung Cancer

  • Received:2011-11-07 Revised:2012-02-03 Published:2012-07-15 Online:2012-07-15
  • Contact: Zuo-Sheng LI

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摘要： 目的：探讨LKB1、VEGFR2在非小细胞肺癌中的表达情况及临床意义。方法：选取临床不同分型及进展程度的非小细胞肺癌78例，分别取材癌组织及癌周正常组织，应用免疫组化方法检测并分析组织中LKB1和VEGFR2的表达情况。结果：LKB1蛋白和VEGFR2在肺癌组织及癌旁正常肺组织中均有表达。LKB1蛋白不同组织来源、不同分化程度及有无淋巴结转移的构成情况差异有统计学意义（P<0.05）。VEGFR2在不同组织来源、分化程度、有无淋巴结转移方面的构成差异有统计学意义（P＜0.05）。结论：LKB1蛋白和VEGFR2在非小细胞肺癌中的表达呈相反趋势，LKB1的低表达与VEGFR2高表达与非小细胞肺癌的肿瘤细胞分化及淋巴结转移有关。

关键词: LKB1蛋白, VEGFR2, 肺癌, 分化, 淋巴结转移

Abstract: Objective: To investigate the protein expressions of LKB1 and VEGFR2 in Non-small Cell Lung Cancer (NSCLC). Methods: The samples of tumor and normal lung tissues were from 78 patients with NSCLC. Immunohistochemical stainings for LKB1 and VEGFR2 were performed and the expression levels of both proteins were analyzed. Results: LKB1 expression as well as VEGFR2 expression was found both in tumor and normal lung tissues. Statistics data showed that significant differences of the positive expressions of LKB1 protein in different organizations, different degree of differentiation and composition of lymph node metastasis(P <0.05). There was also statistically significant in VEGFR2 in different tissue origin, differentiation, and lymph node metastasis(P <0.05). Conclusion: An opposite tendency existed in the expression of LKB1 and VEGFR2 in NSCLC. Moreover, low expression of LKB1 and high expression of VEGFR2 protein were related to the cells differentiation and lymph node metastasis in NSCLC, which may affect the prognosis of lung cancer.

Key words: LKB1, VEGFR2, Lung cancer, Differentiation, Lymph node metastasis