天津医药

• 论著 •    

脓毒症患者血清胆碱酯酶变化及其临床意义

李晨1,柴艳芬2   

  1. 1. 天津医科大学总医院急救中心
    2.
  • 收稿日期:2009-09-09 修回日期:2009-11-23 出版日期:2010-03-15 发布日期:2010-03-15
  • 通讯作者: 李晨

Serum Cholinesterase in Patients with Sepsis and its Clinical Significance

  • Received:2009-09-09 Revised:2009-11-23 Published:2010-03-15 Online:2010-03-15
  • Contact: Chen LI

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摘要： 摘要 目的： 探讨脓毒症患者血清胆碱酯酶（cholinesterase，ChE）变化及其临床意义。方法：检测患者血清ChE浓度，同时对其进行急性生理学与慢性健康状况（APACHE）Ⅱ评分。将患者分为脓毒症组和对照组，其中脓毒症患者分为死亡组和存活组，了解组间血清ChE水平变化及其对病情和预后的影响。结果：（1）脓毒症患者血清ChE水平显著低于对照组患者（P＜0.01）。（2）脓毒症患者死亡组血清ChE水平明显低于存活组（P＜0.05）。（3）脓毒症患者血清ChE水平与其APACHEⅡ评分呈显著负相关关系（r= -0.280，P＜0.05），与血清白蛋白和体重指数呈显著正相关（r分别为0.458和 0.287，P＜0.05）。 结论：血清ChE水平可用于判断脓毒症患者病情严重程度及预后。

关键词: 脓毒症, 血清胆碱酯酶, APACHE Ⅱ评分, 预后

Abstract: Abstract: Objective To explore the changes of serum cholinesterase (ChE) in patients with sepsis and its clinical significance. Methods Estimate serum cholinesterase concentration and acute physiology chronic health evaluation (APACHE) Ⅱ scores in patients. Divide the patients into the sepsis group and the non-sepsis one. Divide the patients with sepsis into the death group and the survival one. Understand the changes of serum ChE levels between the groups and the impact on assessment and prognosis. Results (1) Serum ChE in patients with sepsis group was significantly lower than the control group (P <0.01). (2) In patients with sepsis, the serum ChE levels in the death group were significantly lower compared with the survival one (P <0.05). (3) The serum ChE levels in patients with sepsis were significantly negatively correlated with APACHE Ⅱ scores (r=-0.280, P <0.05), positively correlated with serum albumin and body mass index（r = 0.458 and 0.287，P＜0.05）. Conclusion Serum ChE levels can be used to determine the severity of illness and prognosis in patients with sepsis.

Key words: sepsis, serum-cholinesterase, APACHE Ⅱ score, prognosis