天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (1): 57-60.doi: 10.3969/j.issn.0253-9896.2015.01.014

• 临床研究 • 上一篇    下一篇

幽门螺杆菌和慢性胃炎胃黏膜病理变化的关系研究

李慕然 1， 刘艳迪 1， 唐涛 2， 李文 3△#br# #br#   

  1. 1 天津市人民医院消化科（邮编 300121）， 2病理科， 3 内镜中心
  • 收稿日期:2014-07-14 修回日期:2014-09-10 出版日期:2015-01-15 发布日期:2015-01-30
  • 通讯作者: 李文, E-mail： drliwen115@126.com E-mail:drliwen115@126.com
  • 作者简介:李慕然（1976）， 女， 副主任医师， 博士， 主要从事胃肠道疾病研究
  • 基金资助:
    天津市卫生局科技基金（10KG202）

Study on the relationship between the pathologic change of chronic atrophic gastritis and helicobacer pylori

LI Muran1, LIU Yandi1, TANG Tao2, LI Wen3△#br# #br#   

  1. 1 Department of Gastroenterology, 2 Department ofPathology; 3 Endoscopy Center, Tianjin Union Medicine Centre, Tianjin 300121,China
  • Received:2014-07-14 Revised:2014-09-10 Published:2015-01-15 Online:2015-01-30
  • Contact: E-mail： drliwen115@126.com E-mail:drliwen115@126.com

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摘要： 目的 探讨幽门螺旋杆菌（H.pylori）感染与慢性胃炎胃黏膜病理变化间的关系。 方法 收集 2011 年 11 月—2013 年 3 月天津市人民医院门诊和住院慢性胃炎患者共 250 例， 全部患者行胃镜、病理和 14C 呼气试验检查， 其中慢性萎缩性胃炎（CAG）组 153 例， 非 CAG 组 97 例， 比较 2 组 的 H.pylori 阳性率， 同时比较不同部位（胃窦、胃窦胃体）CAG 患者的 H.pylori 阳性率。 比较不同病理特征下慢性胃炎活动性、炎症程度、萎缩程度、肠化分级的 H.pylori 阳性率。 结果 CAG 组的 H.pylori 阳性率高于非 CAG 组（70.6% vs 35%， χ2=30.552）， CAG 组中胃窦胃体均萎缩患者的 H.pylori 阳性率高于仅胃窦萎缩患者（82.6% vs 65.4%， χ2=4.578）， 随着慢性胃炎活动性、炎症程度、萎缩程度、肠化分级的加重， 其 H.pylori 阳性率增高（χ2分别为 200.643、206.715、73.286、218.432）。 结论 H.pylori 感染与慢性胃炎、慢性萎缩性胃炎关系密切， 尤其与胃窦胃体均萎缩的萎缩性胃炎关系更为密切。

关键词: 胃炎, 螺杆菌, 幽门, 感染, 胃黏膜

Abstract: Abstract： Objective To investigate the correlation between helicobacter pylori (H.pylori) infection with gastric muco⁃ sa pathologic changes in chronic gastritis. Methods A total of 250 patients with chronic gastritis who came to Tianjin Union Medicine Center from November 2011 to March 2013 were collected in this study. Electronic gastroscope examina⁃ tions, pathology and Urea- 14C breath tests were performed in patients. There were 153 cases with chronic atrophic gastritis (CAG group), and 97 cases without chronic atrophic gastritis (non-CAG group). The positive rate of H.pylori was compared between two groups. At the same time the positive rate of H.pylori was compared between different parts of CAG patients. The positive rates of H.pylori were compared between different pathologic features of chronic gastritis (active degree, the de⁃ gree of inflammation, atrophy and intestinal classification). Results The positive rate of H.pylori was higher in CAG pa⁃ tients than that of non-CAG patients (70.6% vs 35%, χ2=30.552). The positive rate of H.pylori was higher in antral and cor⁃ pus atrophy of CAG group than that of antral atrophy (82.6% vs 65.4%, χ2=4.578). With the aggravating activity of gastritis, the inflammation, chronic gastritis, atrophy and intestinal classification, the positive rate of H.pylori was increased (χ2= 200.643, 206.715, 73.286, 218.432). Conclusion H.pylori infection is related with chronic gastritis, chronic atrophic gas⁃ tritis. And antral and corpus atrophy CAG is closely related with H.pylori infection.

Key words: gastritis, helicobacter pylori, infection, gastric mucosa