天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (4): 393-395.doi: 10.11958/j.issn.0253-9896.2015.04.016

• 临床研究 • 上一篇    下一篇

降钙素原在肝硬化并发肝肾综合征患者中的水平变化

孙龙   

  1. 海南医学院附属医院消化内科（邮编570102）
  • 收稿日期:2014-09-16 修回日期:2014-11-13 出版日期:2015-04-15 发布日期:2015-04-13
  • 通讯作者: 孙龙 E-mail:hysunlong@163.com
  • 作者简介:孙龙（1975），男，副教授，博士，主要从事肝脏疾病诊断及治疗方面研究

Changes of procalcitonin level in cirrhosis patients complicated with hepatorenal syndrome

SUN Long   

  1. Department of Gastroenterology, Affiliated Hospital, Hainan Medical College, Haikou 570102, China
  • Received:2014-09-16 Revised:2014-11-13 Published:2015-04-15 Online:2015-04-13
  • Contact: SUN Long E-mail:hysunlong@163.com

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摘要： 摘要：目的观察降钙素原（PCT）在肝硬化并发肝肾综合征（HRS）患者中的水平变化。方法选取肝硬化患者143 例为观察对象，根据其并发HRS 情况分为2 组：非HRS 组115 例、HRS 组28 例，同时以健康体检者40 例作为对照组。所有待测者均测定血清PCT、C 反应蛋白（CRP）、胱抑素-C（Cys-C）、白细胞计数、中性粒细胞比例、血肌酐及尿肌酐水平，比较各组的上述指标变化情况，分析血清PCT 水平与HRS 发病率，以及其与CRP、Cys-C、24 h 内生肌酐清除率（24 h-Ccr）的相关性。结果PCT 升高患者的HRS 发生率明显高于PCT 正常患者（P=0.026）。血清PCT、CRP、Cys-C，HRS 组＞非HRS 组＞对照组（均P＜0.05）；24 h-Ccr，HRS 组＜非HRS 组＜对照组（均P＜0.05），血清PCT 水平与CRP、Cys-C 水平呈正相关，与24 h-Ccr 呈负相关（P＜0.05）。结论检测PCT 水平有助于肝硬化患者感染及肾功能损害的早期判断，在HRS 诊疗中具有重要意义。

关键词: 肝肾综合征, 肝硬化, 降钙素, 降钙素原, 胱抑素-C

Abstract: Abstract：Objective To observe changes of procalcitonin (PCT) level in cirrhosis patients complicated with hepatorenal syn⁃ drome (HRS). Methods Cirrhosis without HRS (Non-HRS group, n=115), cirrhosis with HRS (HRS group, n=28) and control group (40 cases) were enrolled. Levels of serum PCT, C-reactive protein (CRP), Cystatin-C (Cys-C), white blood count, percentage of neutro⁃ phils, serum creatinine and urine creatinine were examined in all participants. Correlation between serum PCT levels and incidence of HRS was analyzed. Correlations between serum PCT levels with CRP, Cys-C, 24 h-Creatinine clearance (24 h-Ccr) were analyzed. Re⁃ sults Among cirrhosis patients, those with increased PCT had higher chance of complication with HRS than those with normal PCT (P=0.026). Levels of serum PCT, CRP and Cys-C are higher in HRS Group than those in Non-HRS group，both which are higher than those incontrol group (P < 0.05); Level of 24 h-Ccr is lower in HRS Group than that in non-HRS group, both of which are lower than that in control group (P < 0.05). Levels of serum PCT positively correlated to levels of serum CRP and Cys-C but, negatively correlated to levels of 24 h-Ccr. Conclusion Serum PCT level contribute to early infection and renal damage in cirrhosis and might play an im⁃ portant role in development of HRS. It is valuable in giving early information of cirrhosis complicated with HRS.

Key words: hepatorenal syndrome, liver cirrhosis, calcitonin, procalcitonin, cystatin-C