天津医药

天津医药 ›› 2022, Vol. 50 ›› Issue (1): 25-29.doi: 10.11958/20211117

• 胆道闭锁专题 • 上一篇    下一篇

瘦素对肝星状细胞活化的调控及其在肝纤维化进展中的作用

王琼1，2，詹江华2△   

  1. 1天津医科大学研究生院（邮编300070）；2天津市儿童医院普外科
  • 收稿日期:2021-05-12 修回日期:2021-09-15 出版日期:2022-01-15 发布日期:2022-01-19
  • 通讯作者: 詹江华 E-mail:zhanjianghuatj@163.com
  • 基金资助:
    新疆维吾尔自治区自然科学基金(2019D01A12)

Research progress of leptin regulation of hepatic stellate cell activation in liver fibrosis

WANG Qiong1, 2, ZHAN Jianghua2△   

  1. 1 Graduate School of Tianjin Medical University, Tianjin 300070, China; 2 Department of General Surgery, 
    Tianjin Children's Hospital
  • Received:2021-05-12 Revised:2021-09-15 Published:2022-01-15 Online:2022-01-19
  • Contact: zhanjianghua E-mail:zhanjianghuatj@163.com

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摘要： 摘要：瘦素是一种主要由白色脂肪组织产生的激素，与肝星状细胞活化有着密切联系。瘦素与其功能性受体结合后可以通过JAK2/STAT3、PI3K/Akt、MAPK等信号通路及相关分子对肝星状细胞的活化产生影响；而肝星状细胞活化是肝纤维化发生发展的关键环节。该文就瘦素与肝星状细胞活化的相关信号通路及分子在肝纤维化发生发展中的作用进行综述，为肝纤维化的治疗提供依据。

关键词: 瘦素, 肝硬化, 肝星状细胞, 信号传导, 活化, 信号通路

Abstract: Abstract: Leptin is a hormone produced mainly by white adipose tissue, and is closely associated with hepatic stellate cell activation. After binding with its functional receptor, leptin can affect the activation of hepatic stellate cells through JAK2/STAT3, PI3K/Akt, MAPK and other signaling pathways and related molecules. The activation of hepatic stellate cells is a key link in the occurrence and development of hepatic fibrosis. In this paper, the relationship between leptin and the signaling pathways and molecules related to hepatic stellate cell activation in the occurrence and development of liver fibrosis is reviewed, in order to provide evidence for the treatment of hepatic fibrosis.

Key words: leptin, liver cirrhosis, hepatic stellate cells, signal transduction, activation, signaling pathways

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