天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (5): 508-510.doi: 10.11958/j.issn.0253-9896.2015.05.016

• 临床研究 • 上一篇    下一篇

急性下呼吸道感染患儿呼吸道病毒与哮喘发作之间的关系

付卓 1， 万莉雅 1， 徐勇胜 1， 郭伟 1， 郑跃杰 2△   

  1. 1天津市儿童医院 （邮编300074）； 2遵义医学院深圳儿童医院
  • 收稿日期:2014-09-30 修回日期:2014-12-31 出版日期:2015-05-15 发布日期:2015-05-25
  • 通讯作者: 郑跃杰 E-mail:yuejiez@sina.com E-mail:fuzhuoertong@163.com
  • 作者简介:付卓 （1977）， 女， 主治医师， 硕士在读， 主要从事儿童呼吸疾病方面研究

Pathogenic analysis of acute lower respiratory infections and its correlation with asthma exacerbations

FU Zhuo1, WAN Liya1, XU Yongsheng1, GUO Wei1, ZHENG Yuejie2△   

  1. 1 Tianjin Children’ s Hospital, Tianjin 300074, China; 2 Zunyi Medical University Shenzhen Children’ s Hospital
  • Received:2014-09-30 Revised:2014-12-31 Published:2015-05-15 Online:2015-05-25
  • Contact: ZHENG Yuejie,E-mail:yuejiez@sina.com E-mail:fuzhuoertong@163.com

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摘要： 摘要： 目的 研究下呼吸道感染（LRTI）患儿全年的呼吸道病毒感染情况以及呼吸道病毒感染导致哮喘发作的关系。方法 选择 2013 年 5 月—2014 年 4 月来我院的急性 LRTI 患儿 231 例为研究对象。从鼻咽抽出液中分离呼吸道合胞病毒 （RSV）、 腺病毒 （AV）、 副流感病毒 （PIV）、 流感病毒 （IFV） 和鼻病毒 （RV） 进行多重 PCR 扩增。应用荧光免疫实验测定血清特异性 IgE 水平， 如果数值超过 0.35 IU/mL 则可认定为特异敏感性。结果 RSV 是引起住院患儿毛细支气管炎的最常见病原， AV 易导致肺炎。哮喘发作更易由 RV 和 IFV 感染引起， 而 IFV 则是支气管炎的主要病原。结论 RV 和 IFV 与具有特应敏感性住院患儿的哮喘急性发作有关。

关键词: 哮喘, 变应原, 正黏病毒科, 鼻病毒属, 儿童, 下呼吸道感染

Abstract: Abstract: Objective To investigate the prevalence of year-round respiratory viral infection in children with lower re⁃ spiratory tract infection (LRTI), and the relationship between respiratory viral infection and allergen sensitization in exacer⁃ bating asthma. Methods A total of 231 hospitalized children with acute LRTI were investigated from May 2013 to April 2014. The 5 most common respiratory viruses were isolated from nasopharyngeal aspirate using multiplex reverse transcrip⁃ tion-polymerase chain reaction, including respiratory syncytial virus (RSV), adenovirus (AV), parainfluenza virus (PIV), in⁃ fluenza virus (IFV) and rhinovirus (RV). Atopic sensitization was defined if more than 1 serum specific immunoglobulin E level measured using immunofluorescence experiment was over 0.35 IU/mL. Results RSV was the most common pathogen of bronchiolitis in hospitalized children through the year. RV or IFV infections were more prevalent in asthma exacerbations compared to other LRTIs. AV was more likely to cause pneumonia. RV and IFV were associated with asthma exacerbations in children with atopic sensitization, but not in nonatopic children. Conclusion RV and IFV are associated with hospital⁃ ization for asthma exacerbation in children with atopic sensitization.

Key words: asthma, allergens, orthomyxoviridae, rhinovirus, child, lower respiratory infection