天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (3): 349-352.doi: 10.11958/20150169

• 临床研究 • 上一篇    下一篇

PD-L1和PD-1在外周T细胞淋巴瘤中的表达及其临床意义

赵越1,卜庆2   

  1. 桂林医学院附属医院肿瘤内科（邮编 541001）
  • 收稿日期:2015-09-15 修回日期:2015-11-03 出版日期:2016-03-15 发布日期:2016-03-15
  • 通讯作者: 卜庆 E-mail:1037536184@qq.com
  • 作者简介: 赵越（1989）， 女， 硕士在读， 主要从事恶性肿瘤的基础与临床研究
  • 基金资助:
    广西壮族自治区卫生和计划生育委员会自筹经费科研课题

The expressions of PD-L1 and PD-1 in peripheral T-cell lymphoma and their clinical significance

ZHAO Yue, BU Qing   

  1. Department of Oncology, Guilin Medical University Affiliated Hospital, Guilin 541001, China
  • Received:2015-09-15 Revised:2015-11-03 Published:2016-03-15 Online:2016-03-15
  • Contact: BU Qing E-mail:1037536184@qq.com

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摘要： 目的 探讨PD-L1和PD-1在外周T细胞淋巴瘤组织中的表达及临床意义。方法 采用免疫组织化学法检测51例外周T细胞淋巴瘤组织（实验组）及20例淋巴结良性增生病变组织（对照组）中PD-L1和PD-1的表达情况，分析其表达与患者临床病理特征及预后之间的关系。结果 实验组PD-L1的表达阳性率高于对照组（74.51%vs35.00% ，?2=9.662，P?0.05），PD-1的表达阳性率高于对照组（66.67%vs 25.00%，?2=10.074，P?0.05），PD-L1和PD-1的表达强度均仅在外周血不同LDH水平间的差异有统计学意义。2程CHOP或EPOCH方案化疗后，PD-L1表达阴性组化疗有效率（RR）优于阳性表达组（84.6% vs 47.4%，?2=5.478, P?0.05），PD-1表达阴性组RR优于表达阳性组（82.4% vs 44.1%，?2=6.755, P?0.05）。PD-L1表达阴性组的中位OS高于表达阳性组（29.8 个月vs 17.6 个月，P?0.05）；PD-1表达阴性组的中位OS高于表达阳性组（29.8 个月vs17.6 个月，P?0.05）。结论 PD-L1和PD-1在外周T细胞淋巴瘤中均表达增高，且与患者外周血高LDH水平及化疗疗效差、生存期短有关，是判断PTCL化疗疗效欠佳及预后不良的因子。

关键词: 外周T细胞淋巴瘤, 程序性死亡1-配体, 程序性死亡因子-1, 免疫组织化学, Kaplan-Meiers评估

Abstract: Objective To investigate the expression levels and clinical significance of PD-L1 and PD-1 in peripheral T-cell lymphoma.Methods Expression levels of PD-L1 and PD-1 in peripheral T-cell lymphoma tissues (test group, n=51) and lymph node optimum pathology (control group, n=20) were detected using immunohistochemistry. Correlations of PD-L1 and PD-1 expressions with clinical pathological parameters and prognosis were analyzed between two groups. Results The expression level of PD-L1 was significantly higher in test group than that in control group（74.51%vs35.00%，?2=9.662，P?0.05）.The expression level of PD-1 was significantly higher in test group than that in control group(66.67%vs 25.00%，?2=10.074，P?0.05).There were significant differences between PD-L1 and PD-1 expressions and peripheral LDH levels involved within test group. After two cycles of CHOP or ECHOP treatments,the response rate(RR) in PD-L1 negative group was higher than that in positive group（84.6%vs47.4%，?2=5.478, P?0.05）and the response rate (RR) in PD-1 negative group was higher than that in positive group（82.4% vs 44.1%，?2=6.755, P?0.05）. The media OS in PD-L1 in negative group was higher than that in positive group（29.8M vs 17.6M，P?0.05）and the media OS in PD-1 negative group was higher than that in positive group（29.8M vs 17.6M，P?0.05）.Conclusion：There was a high level expression of PD-L1 and PD-1 in peripheral T-cell lymphoma,which was closely related with elevated LDH in peripheral blood ,poor response rate and shorter OS. So they could be the factors of worse effect of chemotherapy and poor prognosis.

Key words: peripheral T-cell lymphoma, programmed death 1-ligad, programmed cell death factor-1, immunohistochemistry, Kaplan-Meiers estimate