天津医药 ›› 2016, Vol. 44 ›› Issue (3): 377-380.doi: 10.11958/20150140

• 综述 • 上一篇    下一篇

脑损伤动物模型实施亚低温的模式概述

刘成龙, 陈翀, 孙洪涛   

  1. 天津, 脑创伤与神经疾病研究所, 武警后勤学院附属医院脑科医院, 天津市神经创伤修复重点实验室(邮编 300162)
  • 收稿日期:2015-08-31 修回日期:2015-10-22 出版日期:2016-03-15 发布日期:2016-03-15
  • 通讯作者: 孙洪涛 E-mail:330123959@qq.com
  • 作者简介:刘成龙(1988), 男, 硕士在读, 主要从事中枢神经创伤修复研究
  • 基金资助:
    国家自然科学基金资助项目(81471275, 81271392, 81401067, 81301050)

The overview of the pattern of the mild hypothermia in brain injury animal model

LIU Chenglong, CHEN Chong, SUN Hongtao   

  1. Chinese People′s Armed Police Forces, Tianjin Key Laboratory of Neurotrauma Repair, Tianjin 300162, China
  • Received:2015-08-31 Revised:2015-10-22 Published:2016-03-15 Online:2016-03-15
  • Contact: SUN Hongtao E-mail:330123959@qq.com

摘要: 摘要:脑损伤是全球死亡和致残的主要原因,给社会和家庭带来沉重的负担。脑损伤动物模型的亚低温实验能够为脑损伤的治疗提供新的干预及治疗措施。在大量的脑损伤动物模型的亚低温治疗实验中,其脑保护的作用已经被证实。然而,目前的脑损伤动物实验的亚低温治疗模式尚不明确,其最佳的治疗模式如低温持续的时间、低温诱导的方法以及最佳的温度等仍然未知。由此,本文对脑损伤动物模型的亚低温实验方法进行概述。

关键词: 亚低温, 脑损伤, 动物模型, 治疗模式

Abstract: Abstract: Brain injury is a major cause of worldwide mortality and disability, and it has brought a heavy burden to the society and the family. The hypothermia of brain injury animal models can provide new intervention and therapeutic measures for the brain injury patients. The role of brain protection has been demonstrated in a large number of animal models of brain injury in mild hypothermia experiments. However, the pattern of mild hypothermia in brain injury animals, at present, is not fully delineated, and the optimal pattern, such as the duration, induced method and the topgallant temperature is still unclear. Therefore, this paper summarizes the experimental method of mild hypothermia in brain injury animal model.

Key words: mild hypothermia, brain injury, animal model, treatment pattern