天津医药

天津医药 ›› 2021, Vol. 49 ›› Issue (12): 1335-1339.doi: 10.11958/20211348

• 综述 • 上一篇    下一篇

反复轻型颅脑创伤的颅内病理变化进程及治疗策略研究进展

陈芳莲，葛歆瞳，王栋，雷平△   

  1. 天津医科大学总医院，天津市神经病学研究所，天津老年病学研究所（邮编300052）
  • 收稿日期:2021-06-07 修回日期:2021-08-31 出版日期:2021-12-15 发布日期:2021-12-27
  • 通讯作者: △通信作者 E-mail：leiping1974@163.com E-mail:leiping1974@163.com
  • 作者简介:陈芳莲（1976），女，学士，副主任技师，主要从事创伤性颅脑损伤及慢性创伤性脑病的基础研究。E-mail：chenfanglian1976@ 163.com
  • 基金资助:
    国家自然科学基金资助项目（82071394，82072166）；天津市自然科学基金资助项目（18JCQNJC81100）

The progress in the study of pathological changes and therapeutic strategies for repetitive mild traumatic brain injury

CHEN Fang-lian, GE Xin-tong, WANG Dong, LEI Ping   

  1. Tianjin Medical University General Hospital, Tianjin Neurological Institute, Tianjin Geriatrics Institute, Tianjin 300052, China
    △Corresponding Author E-mail: leiping1974@163.com
  • Received:2021-06-07 Revised:2021-08-31 Published:2021-12-15 Online:2021-12-27

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摘要： 在颅脑创伤患者中，大多数属于轻度颅脑创伤，其中部分患者的脑组织在伤后远期会发生神经退行性变， 此病的相关病理进展机制至今尚未得到充分阐明，严重影响了其治疗策略的探索和发展。在概括中、重型颅脑创伤 后颅内病理改变进程的基础上对比论述已报道的反复轻型颅脑创伤病变进展的机制，并针对上述病理进程的治疗 策略的研究进展予以总结，为今后探索该病长期、综合性的治疗方案提供理论依据。

关键词: 颅脑损伤, 神经变性疾病, 反复轻型颅脑创伤, 神经功能障碍, 神经退行性变

Abstract: Mild traumatic brain injury (mTBI), known as brain concussion, accounts for most of traumatic brain injury (TBI) cases. Neurodegeneration could be observed in brains of some mTBI patients in the long term after injury. The underlying pathological mechanism has not been fully elucidated, which seriously affects the exploration and development of treatment strategies. On the basis of reviewing the procedure of pathological development in injured brain after moderate and severe TBI, this paper contrastively discussed the reported characteristics of pathological changes after repetitive mTBI. In addition, we also summarized the new progress in its therapeutic strategies, which will provide a basis for exploring longterm and comprehensive therapeutic strategies in the future.

Key words: craniocerebral trauma, neurodegenerative diseases, repetitive mild traumatic brain injury, neurological dysfunction, neurodegeneration

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