天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (6): 793-795.doi: 10.11958/20150362

• 药物临床观察 • 上一篇    下一篇

白斑颗粒剂Ⅰ号方治疗白癜风的临床效果观察

詹庆霞， 古昕平， 顾安康， 张峻岭   

  1. 天津市中医药研究院附属医院 （邮编 300120）
  • 收稿日期:2015-11-30 修回日期:2016-04-06 出版日期:2016-06-15 发布日期:2016-07-04
  • 基金资助:
    天津市中医药管理局中医中西医结合科研课题基金资助项目 （13016）

Clinical observation of the efficacy of No. 1 Baiban granules on vitiligo

ZHAN Qingxia, GU Xinping, GU Ankang, ZHANG Junling   

  1. Department of Dermatology, The Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine, Tianjin 300120, China
  • Received:2015-11-30 Revised:2016-04-06 Published:2016-06-15 Online:2016-07-04

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摘要： 摘要： 目的 通过应用皮肤共聚焦激光扫描显微镜 （CLSM） 动态观察中药白斑颗粒剂Ⅰ号方治疗气滞血瘀型白癜风的皮损色素恢复情况及效果。方法 气滞血瘀型白癜风患者 92 例随机分为 2 组， 试验组 49 例予口服白斑颗粒剂Ⅰ号方 3 g， 每日 2 次； 转移因子胶囊每次 6 mg， 每日 3 次； 外用 0.1%糠酸莫米松乳膏每日 1 次， 或 0.1%他克莫司软膏（面部）， 每日 2 次。对照组 43 例仅单纯口服转移因子胶囊每次 6 mg， 每日 3 次； 外用 0.1%糠酸莫米松乳膏（面部除外）， 每日 1 次， 或 0.1%他克莫司软膏 （面部）， 每日 2 次， 治疗 3 个月， 观察 2 组疗效。应用 CLSM 监测皮损处复色情况和色素恢复等级， 以及树枝状黑素细胞数目和炎症细胞浸润的变化。结果 试验组和对照组治疗后较治疗前的复色情况均有明显改善， 试验组总有效率优于对照组（81.63% vs. 69.77%， χ2=3.947， P＜0.05）。CLSM 示试验组白癜风皮损色素恢复等级情况与对照组差异有统计学意义、 树枝状黑素细胞比例高于对照组， 炎症细胞比例低于对照组 （P＜0.05）。结论 白斑颗粒Ⅰ号方治疗气滞血瘀型白癜风效果较为明显。

关键词: 白癜风, 黑素细胞, 共聚焦激光扫描显微镜, 炎症细胞, 白斑颗粒剂Ⅰ号

Abstract: Abstract: Objective To observe the efficacy of No. 1 Baiban granules in the treatment of vitiligo using skin confocal laser scanning microscopy. Methods The study was approved by the hospital ethics committee. Nine-two patients with qi stagnation and blood stasis were collected from Department of Dermatology of the Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine and were randomly assigned to two groups. The experimental group (n=49) received oral Baiban granule Ι, 3 g, twice a day, transfer factor capsules 6 mg, 3 times a day, 0.1% mometasone furoate cream (excluding the face) for external use, once a day, or 0.1% tacrolimus ointment (Afacial), twice a day for 3 months. The control group (n= 43) only received oral transfer factor capsules 6 mg, 3 times a day, 0.1% mometasone furoate cream (except for the face) for external use, once a day, or 0.1% tacrolimus ointment (face), twice a day, treatment for 3 months. The therapeutic effect was observed in two groups. CLSM was used to monitor the compound color and pigment recovery level, and changes of the number of dendritic cells and inflammatory cell infiltration in skin. Results The compound color was improved significantly after treatment in experimental group and control group. The total effective rate was higher in experimental group than that of control group (81.63% vs. 69.77%，χ2=3.947，P＜0.05). Results of CLSM observation showed that the pigment recovery of skin lesion, the proportion of dendritic cells and inflammatory cells were significantly higher in experimental group than those of control group (P < 0.05). Conclusion The treatment effect of No. 1 Baiban granules is more obvious for vitiligo of qi stagnation and blood stasis.

Key words: vitiligo, melanocytes, confocal laser scanning microscopy, inflammatory cell, No. 1 Baiban granules