天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (12): 1440-1442.doi: 10.11958/20160625

• 实验研究 • 上一篇    下一篇

丙泊酚和依托咪酯用于雄性 SD 大鼠麻醉效果的比较

石福， 张益， 喻田△   

  1. 遵义医学院麻醉与器官保护基础研究重点实验室 （邮编 563000）
  • 收稿日期:2016-07-06 修回日期:2016-09-29 出版日期:2016-12-15 发布日期:2017-01-26
  • 通讯作者: 喻田 △通讯作者 E-mail: zyyutian@126.com E-mail:317449197@qq.com
  • 作者简介:石福 （1990）， 男， 硕士在读， 主要从事全麻机制研究
  • 基金资助:
    国家自然科学基金资助项目 （81560237）

Comparison of anesthetic effects of propofol and etomidate in male SD rats

SHI Fu, ZHANG Yi, YU Tian△   

  1. Guizhou Key Laboratory of Anesthesia and Organ Protection， Zunyi Medical College, Zunyi 563000， China
  • Received:2016-07-06 Revised:2016-09-29 Published:2016-12-15 Online:2017-01-26
  • Contact: YU Tian △Corresponding Author E-mail: zyyutian@ 126.com E-mail:317449197@qq.com

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摘要： 摘要： 目的 序贯法测定雄性 SD 大鼠静脉麻醉丙泊酚和依托咪酯的 95%有效剂量 （ED95）， 比较 2 种麻醉药物的效能和麻醉维持时间。方法 28 只雄性 SD 大鼠随机分成丙泊酚组和依托咪酯组， 每组 14 只。以翻正反射作为意识的判定指标。根据公式 Y=Ymin+ （Ymax-Ymin ） / ［1+10log （ED50-X） ×m ］ 拟合大鼠翻正反射消失的剂量-反应性曲线。分别测定丙泊酚和依托咪酯的 ED95 和大鼠静脉注射等效剂量的 2 种药物后麻醉持续时间。结果 测得两组 SD 大鼠丙泊酚 ED95 为 9 mg/kg， 依托咪酯 ED95 为 1.5 mg/kg， 丙泊酚与依托咪酯 ED95 的比值为 6。丙泊酚组大鼠麻醉维持时间 （465.6±18.5） s， 依托咪酯组麻醉维持时间 （233.7±9.3） s， 两组差异有统计学意义 （P＜0.05）。结论 以 ED95 为等效剂量， 丙泊酚组麻醉维持时间长于依托咪酯组。

关键词: 二异丙酚, 依托咪酯, 麻醉, 大鼠, Sprague-Dawley, 序贯法, 95%有效剂量, 翻正反射

Abstract: Abstract: Objective To measure 95% effective doses (ED95) of propofol and etomidate by using up- down intravenous administration method, and compare the potency ratio and the anesthesia duration of them. Methods Twenty eight male SD rats were divided into two groups randomly: the propofol group and the etomidate group．Loss of righting reflex was regarded as the judgment index of unconsciousness. The dose-response curve was made according to the formula of Y=Ymin + (Ymax-Ymin) / [1 + 10log（ED50- X）× m ]. Values of ED95 of propofol and etomidate were calculated, and the anesthesia duration periods after administration of the two equivalent dose drugs were measured respectively. Results The values of ED95 were 9 mg/kg and 1.5 mg/kg for propofol and etomidate. The ED95 ratio for propofol and etomidate was 6. There was a significant difference in anesthesia duration between propofol group (465.6±18.5)s and etomidate group (233.7±9.3)s (P＜ 0.05). Conclusion The anesthesia duration of propofol is longer than that of etomidate, taking the ED95 as equivalent dose.

Key words:  propofol, etomidate, anesthesia, rats, Sprague- Dawley, up- down method, 95% effective dose, righting reflex