天津医药

天津医药 ›› 2017, Vol. 45 ›› Issue (1): 108-112.doi: 10.11958/20161148

• 综述 • 上一篇    

甲状腺激素通过 sirtuins 影响线粒体心肌 保护作用的研究进展

徐启耀 1， 2， 张梅 1△   

  1. 武警后勤学院附属医院
  • 收稿日期:2016-10-14 修回日期:2016-11-21 出版日期:2017-01-15 发布日期:2017-01-15
  • 通讯作者: 张梅 E-mail:dr_xuqiyao@163.com
  • 基金资助:
    锌指基因ZFP580在GDF15降低无复流损伤中的作用研究

Advances in protective effects of thyroid hormone on myocardial mitochondria by sirtuins

XU Qi-yao1， 2， ZHANG Mei1△   

  1. 1 Cardiology Center of the Affiliated Hospital of Logistics University of PAP, Tianjin 300163, China;
    2 Graduate School of Tianjin University of Traditional Chinese Medicine

  • Received:2016-10-14 Revised:2016-11-21 Published:2017-01-15 Online:2017-01-15
  • Contact: ZHANG Mei E-mail:dr_xuqiyao@163.com

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摘要： 摘要： 国内外研究证实甲状腺激素 （TH）、 线粒体对心肌具有一定的保护作用。去乙酰化酶类 sirtuins（SIRTs） 的 部分亚型也能够通过线粒体实现心肌保护作用， 如减少缺血再灌注损伤、 改善病理性心肌肥厚、 改善心衰等。SIRTs 可能通过抑制线粒体膜通道转变孔开放、 抑制线粒体外膜通透性增加、 维持线粒体形态调节平衡、 促进线粒体的生 物合成以及维持受损线粒体的自噬功能而起到心肌保护作用。同时， TH 与 SIRTs 之间也存在相互作用。目前， 线 粒体在细胞凋亡、 坏死中的作用以及对细胞的保护作用也越来越受关注。本文就 SIRTs 如何通过线粒体实现心肌保 护作用及 TH 与 SIRTs 的相互作用对线粒体心肌保护作用的影响进行综述。

关键词: 甲状腺激素类, 线粒体, 心肌, 心脏, 去乙酰化酶

Abstract: Abstract：Many studies have confirmed that thyroid hormone (TH) and mitochondria have protective effects on myocardium. The partial subtype of sirtuins (SIRTs) can also be able to protect myocardium by mitochondria, which includes improving ischemia reperfusion injury, improving the pathological cardiac hypertrophy and improvement of heart failure. SIRTs can achieve the protective effect for myocardium mainly through inhibiting mitochondrial permeability transition poreand mitochondrial membrane permeabilization, maintaining balance of regulation of mitochondrial morphology, promoting mitochondrial biogenesis, maintaining the function of autophagy of impaired mitochondria. At the same time, there is an interaction between TH and SIRTs. At present, the role of mitochondria has become more and more concerned in apoptosis and necrosis and its protective effect on cells. This review summarized the protective effect of SIRTs on myocardium through mitochondrial and the influence of the interaction between SIRTs and TH on myocardial protection of mitochondrial.

Key words: thyroidhormones mitochondria, myocardium, heart, deacetylase, review, sirtuins