天津医药

天津医药 ›› 2017, Vol. 45 ›› Issue (6): 605-609.doi: 10.11958/20170091

• 临床研究 • 上一篇    下一篇

轻度认知障碍工作记忆中 theta 振荡的特征研究

李花娟 1，朱婧 1，张挺 2，宋毅军 1△   

  1. 1 天津医科大学总医院神经内科（邮编 300052）；2 天津医科大学生物医学工程与技术学院
  • 收稿日期:2017-01-19 修回日期:2017-05-07 出版日期:2017-06-15 发布日期:2017-07-05
  • 通讯作者: △通讯作者 E-mail: songyijun2000@126.com E-mail:songyijun2000@126.com
  • 作者简介:李花娟（1991），女，硕士在读，主要从事痴呆和癫痫的临床研究
  • 基金资助:
    天津市应用基础与前沿技术研究计划项目（14JCZDJC35400）；2016 年度天津市“131”创新型人才团队培养工程

The study of the theta oscillation characteristic in working memory in patients with mild cognitive impairment

LI Hua-juan1, ZHU Jing1, ZHANG Ting2, SONG Yi-jun1△   

  1. 1 Department of Neurology, Tianjin Medical University General Hospital, Tianjin 300052, China; 2 School of Biomedical Engineering and Technology, Tianjin Medical University
  • Received:2017-01-19 Revised:2017-05-07 Published:2017-06-15 Online:2017-07-05
  • Contact: △Corresponding Author E-mail: songyijun2000@126.com E-mail:songyijun2000@126.com

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摘要： 目的 探讨轻度认知障碍（MCI）患者工作记忆（WM）障碍 theta 振荡的特征模式。方法 选取 2016 年 1 月—11 月就诊于天津医科大学总医院的 MCI 患者（MCI 组）和健康体检者（对照组）各 15 例。比较 2 组受试者执行 视觉工作记忆任务的行为学差异。同步采集 34 通道脑电信号，应用短时傅里叶变换进行多通道脑电信号的能量空 间分布、时频分布和频谱相干分析。结果 与对照组相比，在工作记忆行为学方面，MCI 组的反应时间明显延长，正 确率明显下降，差异均有统计学意义（P＜0.01）。脑电信号分析显示 2 组在额中线 Fz 通道的 theta 振荡能量最大，但 MCI 组额区 theta 振荡能量密度较对照组明显减低（P＜0.01），额区内部及额-后部脑区之间 theta 振荡的同步性明显 下降（P＜0.05）。结论 MCI 患者额区 theta 振荡的缺失可能是其 WM 障碍的重要机制之一。

关键词: 轻度认知障碍, 工作记忆, theta 振荡, 多通道脑电信号

Abstract: Objective To study the feature of theta oscillation during working memory (WM) dysfunction in patients with mild cognitive impairment (MCI). Methods Fifteen MCI patients (MCI group) and 15 healthy subjects for checkup (control group) in Tianjin Medical University General Hospital from January to November 2016 were recruited. The differences of behavioral results in visual WM tasks were compared between the two groups. Thirty four- channel electroencephalogram (EEG) signals were recorded simultaneously. Short- Time Fourier transform was used to calculate spatial and time-frequency distribution of power and spectral coherence of multi-channel EEGs. Results Compared with control group, MCI group showed significantly longer reaction time and lower accuracy in WM tasks (P＜0.01). The analysis of EEGs revealed that the power of Fz channel was the biggest at frontal midline in both groups. And the power density of theta oscillation was lower at frontal electrode sites in MCI group than that of control group ( P＜0.01), and theta coherence was significantly decreased in frontal region and between frontal-posterior regions ( P＜0.05). Conclusion The absence of theta oscillaton in frontal region may be one of the important reasons of working memory dysfunction for MCI.

Key words: mild cognitive impairment, working memory, theta oscillation, multi-channel electroencephalographs