天津医药

天津医药 ›› 2017, Vol. 45 ›› Issue (6): 610-613.doi: 10.11958/20170308

• 临床研究 • 上一篇    下一篇

丁苯酞对急性脑梗死患者血清炎症因子及 氧化应激水平的影响

安文峰，翟鲁辉△，马玉朝，高朋飞   

  1. 河南省许昌市中心医院神经内科（邮编 461000）
  • 收稿日期:2017-03-09 修回日期:2017-04-25 出版日期:2017-06-15 发布日期:2017-07-05
  • 通讯作者: △通讯作者 E-mail: zhailuhui@sohu.com E-mail:zhailuhui@sohu.com
  • 作者简介:安文峰（1976），男，本科，副主任医师，主要从事脑血管疾病的预防与治疗方面研究

Effects of butylphthalide on serum inflammatory cytokines and oxidative stress products in patients with acute cerebral infarction

AN Wen-feng, ZHAI Lu-hui△, MA Yu-chao, GAO Peng-fei   

  1. Department of Neurology, Xuchang Central Hospital, Xuchang 461000, China
  • Received:2017-03-09 Revised:2017-04-25 Published:2017-06-15 Online:2017-07-05
  • Contact: △Corresponding Author E-mail: zhailuhui@sohu.com E-mail:zhailuhui@sohu.com

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摘要： 目的 探讨丁苯酞对急性脑梗死患者血清炎症因子与氧化应激水平的影响。方法 选取 2014 年 3 月— 2016 年 9 月我院神经内科收治的急性脑梗死患者 120 例，根据治疗方法的不同分为常规治疗组（56 例）和丁苯酞组 （64 例）。常规治疗组给予抗血小板聚集、改善微循环等常规治疗，丁苯酞组在常规治疗的基础上加用丁苯酞注射液 治疗（100 mL 静脉滴注，每日 2 次）。分别检测患者入院时，治疗 7 d、14 d 的血清肿瘤坏死因子（TNF）-α、白细胞介 素（IL）-6、IL-17、IL-23 和氧化应激产物丙二醛（MDA）的水平，并评价其临床疗效。结果 治疗后第 7 天及第 14 天，2 组患者血清 TNF-α、IL-6、IL-17、IL-23，MDA 水平均较治疗前下降，差异均有统计学意义（P < 0.05），同时丁苯 酞组上述指标均较常规治疗组下降（P < 0.05）。2 组均未出现明显的不良反应。结论 丁苯酞可通过抑制炎症反应 和对抗氧化应激等方面来改善急性脑梗死患者的临床症状，改善预后。

关键词: 脑梗死, 炎症, 肿瘤坏死因子 α, 白细胞介素 6, 白细胞介素 17, 丙二醛, 氧化性应激, 丁苯酞

Abstract: Objective To investigate the effects of butylphthalide injection on serum levels of inflammatory factors and oxidative stress products in patients with acute cerebral infarction. Methods A total of 120 patients with acute cerebral infarction were selected in our hospital from March 2014 to September 2016. Patients were divided into conventional treatment group (n=56) and butylphthalide group (n=64) according the therapeutic methods. The conventional treatment group was treated with improving microcirculation and resisting blood platelet aggregation, while the butylphthalide group was injected with butylphthalide (100 mL intravenous drip, twice a day) on the basis of conventional treatment. The levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-17, IL-23 and methane dicarboxylic aldehyde (MDA) were detected before the treatment and 7 days,14 days after the treatment. The clinical efficacy was also accessed. Results The TNF-α, IL-6, IL-17, IL-23 and MDA levels were significantly decreased 7 days and 14 days after the treatment than those before the treatment in two groups of patients (P < 0.05). And the above indexes were also decreased in butylphthalide group than those of conventional treatment group (P < 0.05). No obvious adverse reactions were observed in two groups. Conclusion Butylphthalide can improve the clinical symptoms through the inhibition of inflammation and oxidative stress in patients with acute cerebral infarction.

Key words: brain infarction, inflammation, tumor necrosis factor- alpha, interleukin- 6, interleukin- 17, malondialdehyde, oxidative stress, butylphthalide