天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (4): 432-435.doi: 10.11958/20180081

• 综述 • 上一篇    下一篇

胆道闭锁胆管细胞破坏与修复的研究进展

熊希倩 1，詹江华 2△   

  1. 基金项目：国家自然科学基金资助项目（81570471）；天津市卫生行业重点攻关项目（14KG129） 作者单位：1天津医科大学研究生院（邮编300070）；2天津市儿童医院外科，天津市儿科研究所 作者简介：熊希倩（1991），女，硕士在读，主要从事小儿外科、胆道闭锁方面研究 △通讯作者及审校者 E-mail: zhanjianghuatj@163.com
  • 收稿日期:2018-01-15 修回日期:2018-02-18 出版日期:2018-04-15 发布日期:2018-04-15
  • 通讯作者: 詹江华 E-mail:zhanjianghuatj@163.com
  • 基金资助:
    国家自然科学基金资助项目;天津市卫生行业重点攻关项目

Research progress of biliary atresia cell destruction and repair

XIONG Xi-qian1, ZHAN Jiang-hua2△   

  1. 1 Graduate School of Tianjin Medical University, Tianjin 300070, China; 2 Department of Pediatric Surgery, Tianjin Children’s Hospital, Tianjin Institute of Pediatrics △Corresponding Author and Revisor E-mail: zhanjianghuatj@163.com
  • Received:2018-01-15 Revised:2018-02-18 Published:2018-04-15 Online:2018-04-15
  • Contact: zhanjianghua E-mail:zhanjianghuatj@163.com
  • Supported by:
    ;Fund program:High-Priority Health Projects of Tianjin

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摘要： 摘要：胆道闭锁（BA）是一种由肝内外胆管系统堵塞引发的小儿肝胆外科疾病，如不及时治疗将引起胆汁性肝硬 化，最终发展为肝衰竭而导致患儿死亡。胆管上皮细胞破坏，胆管管腔逐渐狭窄，最终形成纤维条索是BA主要病理 改变。胆管上皮细胞不仅是被动受害者，也被认为是胆管病理学中潜在的效应物。目前，随着国内外对于BA胆管 上皮细胞的研究越来越深入，胆管上皮细胞破坏与修复方面取得了一些进展，本文就胆管结构改变、胆管上皮细胞 破坏、胆管增生与修复、上皮间质转化与肝纤维化的关系等方面作一综述。

关键词: 胆道闭锁, 胆管细胞破坏, 胆管修复, 上皮间质转化, 综述

Abstract: Abstract：Biliary atresia (BA) is a serious digestive system disease caused by the obliteration of intrahepatic and extrahepatic biliary system of infancy. Without prompt treatment, BA can cause biliary cirrhosis and ultimately develop to liver failure, leading child death. Bile duct epithelial cells are destroyed, leading to the formation of gradually narrowed bile duct lumen, and fiber cords are main pathological change of BA. The bile duct epithelial cells are not only the passive victims, but also the potential effect in biliary pathology. At present, with the deepening of the study of BA bile duct epithelial cells at home and abroad, some progress has been made in the destruction and repair of biliary epithelial cells. This article reviews the relationship between epithelial mesenchymal transformation (EMT), the changes in structure of bile duct, bile duct epithelial cell damage, bile duct proliferation and repairing, and hepatic fibrosis.

Key words: biliary atresia, cholangiocyte destruction, bile duct repair, epithelial mesenchymal transition, review