天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (10): 1140-1144.doi: 10.11958/20180650

• 综述 • 上一篇    

放疗导致心脏损伤的发生机制及防治进展

迟红玉 1，曹月娟 2△   

  1. 基金项目：天津市人民医院科研项目（2016YJ027） 作者单位：1天津中医药大学研究生院（邮编300193）；2天津市人民医院 作者简介：迟红玉（1993），女，硕士在读，主要从事心血管病方面研究 △通讯作者 E-mail: drcyj@aliyun.com
  • 收稿日期:2018-04-24 修回日期:2018-05-23 出版日期:2018-10-15 发布日期:2018-11-09
  • 通讯作者: 迟红玉 E-mail:1170156751@qq.com
  • 基金资助:
    曲美他嗪联合养心氏防治放化疗心肌损伤的疗效和作用机制

The mechanism of cardiac injury induced by radiotherapy and its progress of prevention and treatment

CHI Hong-yu1，CAO Yue-juan2△   

  1. 1 Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; 2 Tianjin Union Medical Center △Corresponding Author E-mail:drcyj@aliyun.com
  • Received:2018-04-24 Revised:2018-05-23 Published:2018-10-15 Online:2018-11-09

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摘要： 摘要：放疗作为恶性肿瘤的主要治疗方法之一，广泛应用于乳腺癌、食管癌、肺癌、纵隔肿瘤和淋巴瘤等疾病。 接受放疗患者长时间在X线照射下很容易导致心脏损伤，引起不同程度的放射性心脏病（RIHD），RIHD可以破坏心 脏的任何结构，因此心脏损伤在癌症幸存者中成为危及生命的疾病，而有效的临床管理及防治仍然具有很大的挑战 性。本文对放疗后心脏损伤的表现、发生机制、心脏相关指标监测及防治进展等方面作一综述。

关键词: 放射疗法, 心脏损伤, 辐射损伤, 放射性心脏病

Abstract: Abstract: Radiotherapy is one of the main treatments for malignant tumors, and is widely used today, such as breast cancer, esophageal cancer, lung cancer, mediastinal tumors, and Hodgkin's disease. Patients undergoing radiotherapy are susceptible heart damage of prolonged periods of X-ray irradiation for a long time, causing varying degrees of radiological heart disease (RIHD). RIHD may involve any structure of heart, so cardiac complications become life-threatening diseases in cancer survivors. The effective clinical management and prevention are still quite challenging. This article reviews the manifestation, pathogenesis, monitoring of cardiac related indexes and progressin prevention and treatment of cardiac injury in patients after radiotherapy.

Key words: radiotherapy, heart injuries, radiation injuries, radiological heart disease