放射性心脏损伤相关信号通路及药物干预的研究进展

doi:10.11958/20231637

天津医药 ›› 2024, Vol. 52 ›› Issue (8): 888-892.doi: 10.11958/20231637

放射性心脏损伤相关信号通路及药物干预的研究进展

黄愿¹(), 王刚², 李燕玲³, 谢萍³^,^△()

1 甘肃中医药大学第一临床医学院（邮编730000）
2 兰州大学第一临床医学院
3 甘肃省人民医院心内一科

收稿日期:2023-11-09 修回日期:2023-12-19 出版日期:2024-08-15 发布日期:2024-08-16
通讯作者: △E-mail：pingxie66@163.com
作者简介:黄愿（1997），男，硕士在读，主要从事放射性心脏损伤的机制和防治研究。E-mail：huangyuan_med@163.com
基金资助:
甘肃省自然科学基金项目(22JR5RA665);甘肃省自然科学基金项目(23JRRA1287);甘肃省自然科学基金项目(23JRRA1315);甘肃省科技计划项目(20YF3WA011);兰州市人才创新创业项目(2018-RC-72)

Research progress on signaling pathways and drug intervention in radiation-induced heart disease

HUANG Yuan¹(), WANG Gang², LI Yanling³, XIE Ping³^,^△()

1 The First Clinical College of Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
2 The First Clinical College of Medicine, Lanzhou University
3 Department of Cardiology, Gansu Provincial People's Hospital

Received:2023-11-09 Revised:2023-12-19 Published:2024-08-15 Online:2024-08-16
Contact: △E-mail：pingxie66@163.com

黄愿, 王刚, 李燕玲, 谢萍. 放射性心脏损伤相关信号通路及药物干预的研究进展[J]. 天津医药, 2024, 52(8): 888-892.

HUANG Yuan, WANG Gang, LI Yanling, XIE Ping. Research progress on signaling pathways and drug intervention in radiation-induced heart disease[J]. Tianjin Medical Journal, 2024, 52(8): 888-892.

摘要/Abstract

摘要：

放射性心脏损伤（RIHD）是继发于胸部肿瘤放疗后的心脏毒性事件，已成为除癌细胞毒性外，影响癌症患者机体健康的又一不利因素。信号传导在细胞信息交流中发挥重要作用，RIHD可诱导信号通路失调，阻碍通路功能的正常发挥，从而引起心肌组织发生凋亡、氧化应激及纤维化等病变。现综述RIHD发生发展中失调的相关通路，以及药物干预对通路的调控作用，为防治RIHD提供参考依据。

关键词: 化放疗, 肿瘤, 放射性心脏损伤, 信号通路, 药物干预

Abstract:

Radiation-induced heart disease (RIHD) is a cardiotoxic event secondary to radiotherapy for thoracic tumors, and has become another unfavorable factor affecting the health of cancer patients in addition to cancer cytotoxicity. Signal transduction plays an important role in cellular information exchange. RIHD can induce dysregulation of signaling pathways and hinder the normal function of pathways, thus causing myocardial tissue to undergo lesions such as apoptosis, oxidative stress and fibrosis. Now, we review the relevant pathways that are dysregulated in the development of RIHD, as well as the regulatory effects of drug intervention on these pathways, in order to provide a reference basis for the prevention and treatment of RIHD.

Key words: chemoradiotherapy, tumor, radiation-induced heart disease, signaling pathways, pharmacological interventions

中图分类号:

R541.9

图/表 1

参考文献 37

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放射性心脏损伤相关信号通路及药物干预的研究进展

Research progress on signaling pathways and drug intervention in radiation-induced heart disease

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参考文献 37

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通路	状态	功能
NF-κB/TGF-β1	激活	炎症、纤维化
PI3K/AKT	激活/抑制	纤维化、细胞凋亡、自噬
MAPK	激活/抑制	纤维化、细胞凋亡、氧化应激
TGF-β/Smad	激活	纤维化
Rho/ROCK	激活	纤维化、细胞凋亡、氧化应激
AMPK	激活/抑制	细胞凋亡、氧化应激、自噬
Nrf2/HMGB1	激活	纤维化
通路	干预药物	文献
NF-κB/TGF-β1	氟比洛芬酯、右丙亚胺、吡咯烷二硫代氨基甲酸盐	[12?-14]
PI3K/AKT	当归红芪提取物、氯沙坦、细胞外囊泡	[17-18，20]
MAPK	丹参酮ⅡA磺酸钠、左旋肉碱	[24-25]
TGF-β/Smad	曲美他嗪	[30]
Rho/ROCK	当归红芪多糖	[35]
AMPK	miRNA-223-3p	[36]
Nrf2/HMGB1	当归补血汤	[37]

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