天津医药

天津医药 ›› 2019, Vol. 47 ›› Issue (5): 538-541.doi: 10.11958/20190132

• 综述 • 上一篇    下一篇

甲状腺相关眼病所致干眼发病机制的研究进展

汪东 1，王玲 2，华夏 1△   

  1. 1天津医科大学第二医院（邮编300211）；2天津医科大学
  • 收稿日期:2019-01-16 修回日期:2019-01-24 出版日期:2019-05-15 发布日期:2019-05-15
  • 通讯作者: 华夏 E-mail:cathayhuaxia@163.com
  • 作者简介:基金项目：国家自然科学基金项目（81670816，81870638）；天津市自然科学基金项目（15JCYBJC54600） 作者单位：1天津医科大学第二医院（邮编300211）；2天津医科大学 作者简介：汪东（1966），女，学士，副主任医师，主要从事眼眶疾病的临床和基础研究 △通讯作者 E-mail：cathayhuaxia@163.com
  • 基金资助:
    国家自然科学基金面上项目;天津市自然科学基金面上项目

Research progress on pathogenesis of dry eye induced by thyroid-associated ophthalmopathy

WANG Dong1, WANG Ling2, HUA Xia1△   

  1. 1 Department of Ophthalmopathy, the Second Hospital of Tianjin Medical University, Tianjin 300211, China; 2 Tianjin Medical University △Corresponding Author E-mail: cathayhuaxia@163.com
  • Received:2019-01-16 Revised:2019-01-24 Published:2019-05-15 Online:2019-05-15

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摘要： 摘要：甲状腺相关眼病（TAO）又称为Graves’眼病（GO），属于一种器官特异性自身免疫性疾病，是成人最常见的 眼眶疾病。TAO不仅会导致眼球突出、眼睑回缩、眼球运动障碍等外观上的变化，且患者常常伴发复视、干眼等症 状，其中干眼是“眼部不适感”的重要原因之一，近年来TAO合并干眼的诊疗逐渐受到重视，但其具体发病机制尚不 明确，本文通过分析近年来国内外关于TAO与干眼、眼表疾病等方面的相关研究，针对TAO合并干眼的发病机制予 以综述。

关键词: Graves眼病, 干眼病, 甲状腺激素类, 自身免疫性疾病, 性激素, 眼眶减压术

Abstract: Abstract: Thyroid-associated ophthalmopathy (TAO) also known as Graves’ophthalmopathy is an organ-specific auto-immune disease. TAO is the most common orbital disease in adults. TAO can lead to exophthalmos, upper eyelid retraction and restrictive myopathy, and TAO patients are usually accompanied by diplopia and dry eyes, which is the most important reason for their eye discomfort complains. In recent years, the diagnosis and treatment of dry eye induced by TAO have been paid more attention by ophthalmologist gradually but its pathogenesis is not completely uncovered. Based on the analysis of the related researches on TAO and dry eye at home and abroad in recent years, this paper reviewed potential pathophysiological mechanisms and treatment options that may account for the pathogenesis of dry eye in TAO patients

Key words: Graves ophthalmopathy, xerophthalmia, thyroid hormones, auto-immune diseases, sex hormone, orbital decompression