天津医药

天津医药 ›› 2020, Vol. 48 ›› Issue (4): 338-342.doi: 10.11958/20193358

• 综述 • 上一篇    下一篇

小胶质细胞与脓毒症脑病的研究进展 #br#

庄欣琪 1，谢克亮 2，于泳浩 2△，卢悦淳 1，吕国义 1
  

  1. 1天津医科大学第二医院麻醉科（邮编300211）；2天津医科大学总医院麻醉科，天津市麻醉学研究所
  • 收稿日期:2019-11-05 修回日期:2020-01-08 出版日期:2020-04-15 发布日期:2020-06-23
  • 通讯作者: 于泳浩 E-mail:yyu@tmu.edu.cn
  • 作者简介:庄欣琪（1983），男，博士在读，主治医师，主要从事脓毒症器官保护方面研究
  • 基金资助:
    国家自然科学基金资助项目（81671888，81772043） 

Advances in research on microglia and sepsis associated encephalopathy #br#

ZHUANG Xin-qi1, XIE Ke-liang2, YU Yong-hao2△, LU Yue-chun1, LYU Guo-yi1 #br#   

  1. 1 Department of Anesthesiology, the Second Hospital of Tianjin Medical University, Tianjin 300211, China; 2 Department of
    Anesthesiology, Tianjin Medical University General Hospital, Tianjin Institute of Anesthesiology
  • Received:2019-11-05 Revised:2020-01-08 Published:2020-04-15 Online:2020-06-23
  • Contact: YU Yong-hao E-mail:yyu@tmu.edu.cn

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摘要： 脓毒症脑病（SAE）以脑功能障碍为主要特征，是脓毒症患者的常见并发症，严重影响预后和生存质量。近
期研究发现，小胶质细胞作为中枢神经系统内的免疫细胞，在脓毒症条件下可发生炎性改变，促进中枢炎症反应和
SAE的发展。以小胶质细胞作为靶点可能为治疗 SAE提供新的思路和方向。本文简述小胶质细胞的特性及其与
SAE的关系，分析小胶质细胞活化对中枢神经系统的影响，探讨调节小胶质细胞的信号通路，并对其未来临床应用进
行了展望。

关键词: 脓毒症, 脑, 小神经胶质细胞, 炎症, 综述

Abstract: Sepsis associated encephalopathy (SAE), characterized by brain dysfunction, is a common complication in
septic patients and seriously affects the prognosis and quality of life. Recent researches have discovered that microglia, as the immune cells in the central nervous system, can produce inflammatory transformation under septic condition and promote the development of cerebral inflammation and SAE. Targeting microglia may provide new ideas and directions for the treatment of SAE. In this paper, the characteristics of microglia were briefly described, and the relationship between microglia and SAE was expounded. The effects of microglia activation on the central nervous system were analyzed, the signaling pathway for microglia regulation was discussed, and its clinical application in the future was prospected.

Key words: sepsis, brain, microglia, inflammation, review

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