天津医药

天津医药 ›› 2020, Vol. 48 ›› Issue (9): 908-912.doi: 10.11958/20193570

• 综述 • 上一篇    

2型固有淋巴细胞在变应性疾病中的研究进展

刘力，邹映雪△   

  1. 天津市儿童医院（天津大学儿童医院）内科（邮编300074）
  • 收稿日期:2019-12-03 修回日期:2020-05-06 出版日期:2020-09-15 发布日期:2020-09-22
  • 通讯作者: 邹映雪 E-mail:xue11235813@163.com

Advances in the study of type 2 innate lymphocytes in allergic diseases

LIU Li, ZOU Ying-xue△   

  1. Department of Internal Medicine, Tianjin Children’s Hospital (Children’s Hospital of Tianjin University),
     Tianjin 300074, China
  • Received:2019-12-03 Revised:2020-05-06 Published:2020-09-15 Online:2020-09-22
  • Contact: YING XUE ZOU E-mail:xue11235813@163.com

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摘要： 摘要：固有淋巴细胞（ILCs）是一类独特的免疫效应细胞，近十年来受到广泛关注，特别是2型固有淋巴细胞（ILC2）在变应性疾病、自身免疫性疾病中的作用备受重视。ILC2参与黏膜免疫的形成、组织损伤的修复及重塑，在抗感染、调控炎症、维持免疫稳态中起着重要作用。在过敏性鼻炎、哮喘、食物过敏、嗜酸性粒细胞性食管炎的炎症反应中均有ILC2参与，是不能被忽视的环节，本文就ILC2在变应性疾病中的研究进展做一综述。

关键词: 2型固有淋巴细胞, 变应性疾病, 变应性鼻炎, 哮喘, 特应性皮炎

Abstract: Abstract：Innate lymphocytes (ILCs) are a unique class of immune effector cells, which has been widely concerned in the past decade, especially the role of type 2 innate lymphocyte (ILC2) in allergic diseases and autoimmune diseases. ILC2 is involved in the formation of mucosal immunity, repairing and remodeling of tissue damage, and plays an important role in fighting infection, regulating inflammation and maintaining immune homeostasis. ILC2 is involved in the inflammatory response of allergic rhinitis, asthma, food allergy and eosinophil esophagitis, which cannot be ignored. This paper reviews the research progress of ILC2 in allergic diseases.

Key words: group 2 innate lymphoid cells, allergic disease, allergic rhinitis, asthma, atopic dermatitis

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