天津医药

天津医药 ›› 2020, Vol. 48 ›› Issue (9): 903-907.doi: 10.11958/20193232

• 综述 • 上一篇    下一篇

下一代测序技术在结直肠癌诊疗中的应用

陈如萍1，2，刘蕊2△   

  1. 1天津医科大学研究生院（邮编300070）；2天津市人民医院检验学部
  • 收稿日期:2019-10-24 修回日期:2020-06-23 出版日期:2020-09-15 发布日期:2020-09-22
  • 通讯作者: 刘蕊 E-mail:lcjyzdx@163.com

The application of next generation sequencing in the diagnosis and treatment of colorectal cancer#br#

CHEN Ru-ping1, 2, LIU Rui2△   

  1. 1 Graduate School of Tianjin Medical University, Tianjin 300070, China;
     2 Department of Clinical Laboratory, Tianjin Union Medical Center
  • Received:2019-10-24 Revised:2020-06-23 Published:2020-09-15 Online:2020-09-22

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摘要： 摘要：下一代测序（NGS）技术在结直肠癌（CRC）临床诊断及治疗中的潜在应用价值已成为研究热点。NGS不仅可以用于检测基因突变以利于CRC早期筛查，还能够指导靶向药物的选择以及预测疗效和评估预后。本文就近年来NGS技术在结直肠癌临床诊疗中的应用进行综述。

关键词: 结直肠肿瘤, 基因检测, 分子靶向治疗, 预后, 下一代测序

Abstract: Abstract: The potential application value of next generation sequencing (NGS) technology in the clinical diagnosis and treatment of colorectal cancer (CRC) has become a research hotspot. NGS can be used not only to detect gene mutations in the early CRC screening, but also to guide the selection of targeted drugs, the predicting of the efficacy and the evaluation of the prognosis. This paper reviews the applications of NGS technology in clinical diagnosis and treatment of CRC in recent years.

Key words: colorectal neoplasms, genetic testing, molecular targeted therapy, prognosis, next generation sequencing

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