天津医药

天津医药 ›› 2020, Vol. 48 ›› Issue (11): 1079-1082.doi: 10.11958/20201022

• 临床研究 • 上一篇    下一篇

中性粒细胞/淋巴细胞比率与转移性胃癌患者预后的关系

李美1，赵峰2△，俞婷1   

  1. 1东南大学附属中大医院（江北院区）检验科（邮编210035），2肿瘤科
  • 收稿日期:2020-04-15 修回日期:2020-07-20 出版日期:2020-11-15 发布日期:2020-11-15

Relationship between neutrophil / lymphocyte ratio and prognosis in patients with metastatic gastric cancer

LI Mei1, ZHAO Feng2△, YU Ting1   

  1. 1 Department of Laboratory, 2 Department of Oncology, Zhongda Hospital Affiliated to Southeast University (Jiangbei District), Nanjing 210035, China
  • Received:2020-04-15 Revised:2020-07-20 Published:2020-11-15 Online:2020-11-15

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摘要： 目的　研究中性粒细胞/淋巴细胞比率（NLR）与转移性胃癌患者预后的关系。方法　回顾性分析148例转移性胃癌患者的临床病理资料，根据NLR中位数将患者分为高NLR组（NLR≥2.51，73例）与低NLR组（NLR＜2.51，75例）。比较2组患者的临床病理特点和总生存率，Cox多因素分析确定影响转移性胃癌总生存率的危险因素，Kaplan-Meier法绘制2组患者的生存曲线。结果　高NLR组转移部位≥2、肝脏转移、腹膜转移、幽门螺旋杆菌感染及癌胚抗原（CEA）≥5 μg/L比例明显高于低NLR组（P＜0.05）。生存分析结果显示，高NLR组的生存时间明显短于低NLR组（10个月vs. 22个月，Log-rank χ2=4.125，P＜0.05）。高NLR组患者随访1、3、5年的总生存率明显低于低NLR组患者（26.03% vs. 65.33%、6.85% vs. 16.00%、0 vs. 4.00%，均P＜0.05）。Cox多因素分析结果表明肝脏转移、腹膜转移及NLR≥2.51均是影响转移性胃癌患者总生存率的独立危险因素。结论　NLR可以预测转移性胃癌患者的远期生存情况，NLR≥2.51的患者远期生存较差。

关键词: 胃肿瘤, 癌, 肿瘤转移, 预后, 危险因素, 中性粒细胞/淋巴细胞比率, 转移性胃癌

Abstract: Objective　To study the relationship between neutrophil / lymphocyte ratio (NLR) and the prognosis of patients with metastatic gastric cancer. Methods　The clinical and pathological data of 148 patients with metastatic gastric cancer were retrospectively analyzed. The patients were divided into high NLR group (NLR≥2.51, n=73) and low NLR group (NLR <2.51, n=75). The clinical pathological characteristics and overall survival rate were compared between the two groups of patients. Cox multivariate analysis was used to determine the risk factors affecting the overall survival rate of metastatic gastric cancer. The Kaplan-Meier method was used to make the survival curves of the two groups of patients. Results　The proportion of metastatic site≥2, liver metastasis, peritoneal metastasis, helicobacter pylori infection and CEA≥5 μg/L was significantly higher in high NLR group than that of low NLR group (P＜0.05). The results of survival analysis showed that the survival time was significantly shorter in the high NLR group than that of the low NLR group (10 months vs. 22 months, P＜0.05). The overall survival rates for 1, 3, and 5 years of follow-up were significantly lower in patients in the high NLR group than those in the low NLR group (26.03% vs. 65.33%, 6.85% vs. 16.00%, 0 vs. 4.00%, P＜0.05). Cox multivariate analysis showed that liver metastasis, peritoneal metastasis and NLR≥2.51 were independent risk factors that affect the overall survival rate of patients with metastatic gastric cancer. Conclusion　NLR can predict the long-term survival of patients with metastatic gastric cancer. Patients with NLR≥2.51 have poor long-term survival.

Key words: stomach neoplasms, carcinoma, neoplasm metastasis, prognosis, risk factors, neutrophil/lymphocyte ratio, metastatic gastric cancer