天津医药

天津医药 ›› 2021, Vol. 49 ›› Issue (5): 550-555.doi: 10.11958/20202907

• 综述 • 上一篇    下一篇

基于α-突触核蛋白的帕金森病动物模型研究进展

杜可晨1，2，3，邹春林1，2，3△   

  1. 1广西医科大学转化医学研究中心（邮编530021），2长寿与老年相关疾病教育部重点实验室，3广西医科大学基础医学院
  • 收稿日期:2020-10-21 修回日期:2021-02-09 出版日期:2021-05-15 发布日期:2021-05-25
  • 通讯作者: 邹春林 E-mail:zouchunlin@sohu.com
  • 基金资助:
    国家自然科学基金资助项目（81971191，81670750）

Current progress in α-synuclein-based animal models of Parkinson's disease

DU Ke-chen1, 2, 3, ZOU Chun-lin1, 2, 3△   

  1. 1 Center for Translational Medicine, 2 Key Laboratory of Longevity and Aging-related Diseases, Ministry of Education, 
    3 School of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, China
  • Received:2020-10-21 Revised:2021-02-09 Published:2021-05-15 Online:2021-05-25
  • Supported by:
    Funded by National Natural Science Foundation of China

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摘要： 摘要：帕金森病（PD）是第二常见的神经退行性疾病。已有研究表明α-突触核蛋白（α-syn）与PD的发病有着密切的关系。国内外研究者利用α-syn的异位表达、过表达或脑内注射等方法来建立PD动物模型。近年来，α-突触核蛋白预制原纤维（α-syn PFFs）已用于动物模型的构建。α-syn PFFs在研究PD的起源及神经元病变传播中起促进作用。这些模型与传统化学毒素模型相比能够更好地复制PD患者特征性病理改变。本文基于α-syn的PD动物模型的研究进展进行综述。

关键词: 帕金森病；α突触核蛋白；模型, 动物；Lewy体；α-突触核蛋白预制原纤维

Abstract:

Abstract: Parkinson's disease (PD) is the second most common neurodegenerative disease. A number of studies have shown that α-synuclein (α-syn) is closely related to the pathogenesis of Parkinson's disease. Domestic and foreign researchers have established PD animal models via the ectopic expression, overexpression or intracerebral injection of α-syn. In recent years, α-synuclein preformed fibrils (α-syn PFFs) have been used in the construction of animal models. α-syn PFFs play an important role in the study of the origin of PD and the transmission of neuronal degeneration. Compared with the toxin-induced models, these models can better reproduce the characteristics of pathological changes of PD patients. In this article, we mainly reviewed the research progress in α-synuclein-based animal models of PD.

Key words: Parkinson's disease, alpha-synuclein, models, animal, Lewy bodies, a-synuclein preformed fibrils