天津医药

天津医药 ›› 2022, Vol. 50 ›› Issue (4): 433-438.doi: 10.11958/20212451

• 综述 • 上一篇    下一篇

HMGB1和TLR4在ARDS中作用的研究进展

舒小燚，李有霞，范绍辉，王红嫚△   

  1. 遵义医科大学第五附属（珠海）医院呼吸与危重症医学科（邮编519100）
  • 收稿日期:2021-11-01 修回日期:2022-01-06 出版日期:2022-04-15 发布日期:2022-04-15
  • 通讯作者: △通信作者 E-mail：2496453591@qq.com E-mail:2496453591@qq.com
  • 作者简介:舒小燚（1995），女，硕士在读，主要从事呼吸危重症急救方面研究。E-mail：1099646832@qq.com
  • 基金资助:
    国家自然科学基金资助项目（81960023）；贵州省卫生健康委科学技术基金项目（gzwkj2021-093）

Research progress on the role of high mobility group protein B1 and Toll- like receptor 4 in ARDS

SHU Xiaoyi, LI Youxia, FAN Shaohui, WANG Hongman△   

  1. Department of Respiratory and Critical Care Medicine, the Fifth Affiliated (Zhuhai) Hospital of
    Zunyi Medical University, Zhuhai 519100, China
    △Corresponding Author E-mail: 2496453591@qq.com
  • Received:2021-11-01 Revised:2022-01-06 Published:2022-04-15 Online:2022-04-15
  • Contact: △E-mail：2496453591@qq.com E-mail:2496453591@qq.com

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摘要： 急性呼吸窘迫综合征（ARDS）的发病机制复杂，炎症反应在ARDS的病理进程中具有关键作用。高迁移率 族蛋白B1（HMGB1）和Toll样受体4（TLR4）是促发炎性反应的关键介质，许多证据表明HMGB1和TLR4在ARDS中 发挥重要作用，可能成为ARDS的治疗靶点。就HMGB1、TLR4和HMGB1/TLR4信号通路在ARDS炎症发展中的作用 及相关治疗进展进行综述。

关键词: HMGB1蛋白质, Toll样受体4, 呼吸窘迫综合征, 成人, 急性肺损伤, 病原体相关分子模式分子

Abstract: The pathogenesis of acute respiratory distress syndrome (ARDS) is complex, inflammation plays an important role in the pathological process of ARDS. Many studies have shown that high mobility group box 1 protein (HMGB1) and tolllike receptor 4 (TLR4), as inflammatory mediators, are important components in ARDS, which may become the therapeutic target of ARDS. This article reviews the role of HMGB1, TLR4 and HMGB1/TLR4 signaling pathway in the development of inflammation and the related treatment progression of ARDS.

Key words: HMGB1 protein, Toll-like receptor 4, respiratory distress syndrome, adult, acute lung injury, pathogenassociated molecular pattern molecules

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