脓毒症相关肠道功能障碍发病机制的研究进展

doi:10.11958/20221492

天津医药 ›› 2023, Vol. 51 ›› Issue (3): 333-336.doi: 10.11958/20221492

• 综述 • 上一篇

脓毒症相关肠道功能障碍发病机制的研究进展

胡英山¹(), 王晶晶², 高红梅^△()

1 天津医科大学一中心临床学院（邮编300190）
2 天津市第一中心医院重症医学科

收稿日期:2022-09-15 修回日期:2022-11-11 出版日期:2023-03-15 发布日期:2023-03-02
通讯作者: 高红梅 E-mail:546407971@qq.com;ghm182@163.com
作者简介:胡英山（1996），男，硕士在读，主要从事脓毒症肠道功能障碍相关方面研究。E-mail：546407971@qq.com
基金资助:
天津市科技计划项目(21JCYBJC00090);天津市卫生健康科技计划项目(ZC20012)

Research progress in the pathogenesis of sepsis-related intestinal dysfunction

HU Yingshan¹(), WANG Jingjing², GAO Hongmei^△()

1 The First Central Clinical College of Tianjin Medical University, Tianjin 300190, China
2 Department of Intensive Care Medicine, Tianjin First Central Hospital

Received:2022-09-15 Revised:2022-11-11 Published:2023-03-15 Online:2023-03-02
Contact: GAO Hongmei E-mail:546407971@qq.com;ghm182@163.com

胡英山, 王晶晶, 高红梅. 脓毒症相关肠道功能障碍发病机制的研究进展[J]. 天津医药, 2023, 51(3): 333-336.

HU Yingshan, WANG Jingjing, GAO Hongmei. Research progress in the pathogenesis of sepsis-related intestinal dysfunction[J]. Tianjin Medical Journal, 2023, 51(3): 333-336.

摘要/Abstract

摘要：

脓毒症相关肠道功能障碍是脓毒症患者较常见，但易被忽视的并发症。其发病机制尚未完全明确，目前可能的机制包括：肠道微生态失衡、异常的肠道细胞死亡、线粒体功能障碍等。由于此并发症的发病机制不清，且现有的治疗对患者预后的改善程度有限。该文就对脓毒症相关肠道功能障碍发病机制的研究现状进行综述，以期为脓毒症相关肠道功能障碍寻找新的临床治疗方案。

关键词: 脓毒症, 肠疾病, 细胞凋亡, 铁死亡, 细胞焦亡, 线粒体自噬, 肠道微生态

Abstract:

Sepsis-related intestinal dysfunction is a common but neglected complication in patients with sepsis. Its pathogenesis is not fully understood. At present, possible mechanisms include intestinal microecological imbalance, abnormal intestinal cell death and mitochondrial dysfunction. Because the pathogenesis of this complication is unclear, and existing therapeutic means offer limited improvement in patient prognosis, this article reviews the current research status of the pathogenesis of sepsis related intestinal dysfunction in order to find new clinical treatment options for sepsis related intestinal dysfunction.

Key words: sepsis, intestinal diseases, apoptosis, ferroptosis, pyroptosis, mitophagy, intestinal microecology

中图分类号:

R574.4

参考文献 39

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脓毒症相关肠道功能障碍发病机制的研究进展

Research progress in the pathogenesis of sepsis-related intestinal dysfunction

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